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Cerebral Autoregulation in Sick Infants: Current Insights

Kooi, E. M. W. & Richter, A. E., Sep-2020, In : Clinics in perinatology. 47, 3, p. 449-467 19 p.

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DOI

Cerebrovascular autoregulation is the ability to maintain stable cerebral blood flow within a range of cerebral perfusion pressures. When cerebral perfusion pressure is outside the limits of effective autoregulation, the brain is subjected to hypoperfusion or hyperperfusion, which may cause vascular injury, hemorrhage, and/or hypoxic white matter injury. Infants born preterm, after fetal growth restriction, with congenital heart disease, or with hypoxic-ischemic encephalopathy are susceptible to a failure of cerebral autoregulation. Bedside assessment of cerebrovascular autoregulation would offer the opportunity to prevent brain injury. Clinicians need to know which patient populations and circumstances are associated with impaired/absent cerebral autoregulation.

Original languageEnglish
Pages (from-to)449-467
Number of pages19
JournalClinics in perinatology
Volume47
Issue number3
Publication statusPublished - Sep-2020

    Keywords

  • Cerebral autoregulation, Cerebral hemodynamics, Preterm infant, Fetal growth restriction, Hypoxic-ischemic encephalopathy, Congenital heart disease, Neonatal surgery, NEAR-INFRARED SPECTROSCOPY, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, TISSUE OXYGEN EXTRACTION, PRETERM INFANTS, BLOOD-FLOW, CEREBROVASCULAR AUTOREGULATION, MAGNESIUM-SULFATE, PREMATURE-INFANTS, NECROTIZING ENTEROCOLITIS, PRESSURE AUTOREGULATION

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