Publication

Cerebral and splanchnic oxygenation and necrotizing enterocolitis in preterm infants

Schat, T. E., 2015, [Groningen]: University of Groningen. 122 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Chapter 1

    Final publisher's version, 1 MB, PDF document

  • Chapter 2

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  • Chapter 3

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  • Chapter 5

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  • Title and contents

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  • Chapter 7

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  • Chapter 8

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  • Complete thesis

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  • Propositions

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  • Chapter 6

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  • Chapter 4

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DOI

  • Trijntje Eelkje Schat
Necrotizing enterocolitis (NEC) is the most common and deadliest gastrointestinal disease in preterm infants. Mortality rates of NEC can be as high as 40%. Furthermore, NEC is associated with adverse neurological outcomes at school age and gastrointestinal complications in the long term, such as short bowel syndrome. Currently, we lack reliable preventive and predictive diagnostic tools to be able to minimize these devastating short- and long-term outcomes.

In this thesis we investigated the potential role of near-infrared spectroscopy (NIRS) in the diagnostic process of NEC. For this purpose we measured cerebral, liver, and intestinal oxygenation values in preterm infants suspected of having NEC and in preterm infants with an increased risk of developing NEC later on. We found that NIRS can be used to identify infants who go on to develop NEC as well as infants with established NEC who will develop a complicated course of this disease.

Additionally, we established that a blood pressure dependent cerebral blood flow might be the underlying mechanism responsible for the adverse neurological development observed in preterm infants who survived NEC. This warrants close monitoring of cerebral oxygenation and blood pressure in preterm infants with NEC.

In conclusion, NIRS might be an important method to predict and diagnose NEC timely in preterm infants, and might therefore minimize the adverse short- and long-term consequences with which NEC is associated.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
  • Bos, Arie, Supervisor
  • Kooi, Elisabeth, Co-supervisor
  • Hulscher, Jan, Co-supervisor
  • Heineman, Erik, Assessment committee
  • van Bel, Frank, Assessment committee, External person
  • Reiss, I., Assessment committee, External person
Award date1-Jul-2015
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-6295-207-2
Electronic ISBNs978-94-6295-214-0
Publication statusPublished - 2015

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