Publication

Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

Vogt, L. M., Boekschoten, M. V., de Groot, P. J., Faas, M. M. & de Vos, P., Oct-2015, In : Journal of Functional Foods. 18, p. 520-531 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vogt, L. M., Boekschoten, M. V., de Groot, P. J., Faas, M. M., & de Vos, P. (2015). Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells. Journal of Functional Foods, 18, 520-531. https://doi.org/10.1016/j.jff.2015.08.011

Author

Vogt, Leonie M. ; Boekschoten, Mark V. ; de Groot, Philip J. ; Faas, Marijke M. ; de Vos, Paul. / Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells. In: Journal of Functional Foods. 2015 ; Vol. 18. pp. 520-531.

Harvard

Vogt, LM, Boekschoten, MV, de Groot, PJ, Faas, MM & de Vos, P 2015, 'Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells', Journal of Functional Foods, vol. 18, pp. 520-531. https://doi.org/10.1016/j.jff.2015.08.011

Standard

Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells. / Vogt, Leonie M.; Boekschoten, Mark V.; de Groot, Philip J.; Faas, Marijke M.; de Vos, Paul.

In: Journal of Functional Foods, Vol. 18, 10.2015, p. 520-531.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vogt LM, Boekschoten MV, de Groot PJ, Faas MM, de Vos P. Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells. Journal of Functional Foods. 2015 Oct;18:520-531. https://doi.org/10.1016/j.jff.2015.08.011


BibTeX

@article{5a0fcd8cdf714609bd843cfb266b2e65,
title = "Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells",
abstract = "The immunomodulatory and epithelial barrier effects of cellulose as a dietary fibre were studied to analyse the potential for use in health promoting functional foods. Reporter assays demonstrated cellulose-mediated activation through TLR/MyD88 dependent-, and independent pathways. Microchip analysis of human PBMCs showed that cellulose induced upregulation of three NF-kappa B related genes, i.e. CD40 molecule, interleukin 1 receptor antagonist (IL-1Ra), and interleukin-1 receptor-associated kinase 1 (IRAK1). Five upregulated genes related specifically to TLR signalling were identified, i.e. interleukin 1 receptor antagonist (IL-1Ra), interleukin-1 receptor-associated kinase 1 (IRAK1), jun proto-oncogene, mitogen-activated protein kinase kinase 3 (MAP2K3), and mitogen-activated protein kinase 13 (MAPK13). Cellulose did not affect T84 intestinal epithelial cell resistance. Cellulose does not directly affect T84 cell barrier function. However, it alters gene expression in human immune cells and activates TLR and non-TLR related pattern recognition pathways, indicating the immunomodulatory potential of cellulose as major component of root pulp byproduct. (C) 2015 Elsevier Ltd. All rights reserved.",
keywords = "Cellulose, Dietary fibre, NF-kappa B, TLR, INTESTINAL EPITHELIAL-CELLS, INNATE IMMUNE-RESPONSE, PROTEIN-KINASE-C, DIETARY FIBER, T-CELLS, IN-VIVO, INTERLEUKIN-1 RECEPTOR, ILLUMINA MICROARRAY, SIGNALING PATHWAYS, BARRIER FUNCTION",
author = "Vogt, {Leonie M.} and Boekschoten, {Mark V.} and {de Groot}, {Philip J.} and Faas, {Marijke M.} and {de Vos}, Paul",
year = "2015",
month = "10",
doi = "10.1016/j.jff.2015.08.011",
language = "English",
volume = "18",
pages = "520--531",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - Cellulose alters the expression of nuclear factor kappa B-related genes and Toll-like receptor-related genes in human peripheral blood mononuclear cells

AU - Vogt, Leonie M.

AU - Boekschoten, Mark V.

AU - de Groot, Philip J.

AU - Faas, Marijke M.

AU - de Vos, Paul

PY - 2015/10

Y1 - 2015/10

N2 - The immunomodulatory and epithelial barrier effects of cellulose as a dietary fibre were studied to analyse the potential for use in health promoting functional foods. Reporter assays demonstrated cellulose-mediated activation through TLR/MyD88 dependent-, and independent pathways. Microchip analysis of human PBMCs showed that cellulose induced upregulation of three NF-kappa B related genes, i.e. CD40 molecule, interleukin 1 receptor antagonist (IL-1Ra), and interleukin-1 receptor-associated kinase 1 (IRAK1). Five upregulated genes related specifically to TLR signalling were identified, i.e. interleukin 1 receptor antagonist (IL-1Ra), interleukin-1 receptor-associated kinase 1 (IRAK1), jun proto-oncogene, mitogen-activated protein kinase kinase 3 (MAP2K3), and mitogen-activated protein kinase 13 (MAPK13). Cellulose did not affect T84 intestinal epithelial cell resistance. Cellulose does not directly affect T84 cell barrier function. However, it alters gene expression in human immune cells and activates TLR and non-TLR related pattern recognition pathways, indicating the immunomodulatory potential of cellulose as major component of root pulp byproduct. (C) 2015 Elsevier Ltd. All rights reserved.

AB - The immunomodulatory and epithelial barrier effects of cellulose as a dietary fibre were studied to analyse the potential for use in health promoting functional foods. Reporter assays demonstrated cellulose-mediated activation through TLR/MyD88 dependent-, and independent pathways. Microchip analysis of human PBMCs showed that cellulose induced upregulation of three NF-kappa B related genes, i.e. CD40 molecule, interleukin 1 receptor antagonist (IL-1Ra), and interleukin-1 receptor-associated kinase 1 (IRAK1). Five upregulated genes related specifically to TLR signalling were identified, i.e. interleukin 1 receptor antagonist (IL-1Ra), interleukin-1 receptor-associated kinase 1 (IRAK1), jun proto-oncogene, mitogen-activated protein kinase kinase 3 (MAP2K3), and mitogen-activated protein kinase 13 (MAPK13). Cellulose did not affect T84 intestinal epithelial cell resistance. Cellulose does not directly affect T84 cell barrier function. However, it alters gene expression in human immune cells and activates TLR and non-TLR related pattern recognition pathways, indicating the immunomodulatory potential of cellulose as major component of root pulp byproduct. (C) 2015 Elsevier Ltd. All rights reserved.

KW - Cellulose

KW - Dietary fibre

KW - NF-kappa B

KW - TLR

KW - INTESTINAL EPITHELIAL-CELLS

KW - INNATE IMMUNE-RESPONSE

KW - PROTEIN-KINASE-C

KW - DIETARY FIBER

KW - T-CELLS

KW - IN-VIVO

KW - INTERLEUKIN-1 RECEPTOR

KW - ILLUMINA MICROARRAY

KW - SIGNALING PATHWAYS

KW - BARRIER FUNCTION

U2 - 10.1016/j.jff.2015.08.011

DO - 10.1016/j.jff.2015.08.011

M3 - Article

VL - 18

SP - 520

EP - 531

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -

ID: 28866265