Cellular senescence and the aging brainChinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J. & Andersen, J. K., Aug-2015, In : Experimental Gerontology. 68, p. 3-7 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of non-neuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies.
|Number of pages||5|
|Publication status||Published - Aug-2015|
- INFLAMMATORY CYTOKINE SECRETION, DNA-DAMAGE RESPONSE, IN-VIVO, NEURODEGENERATIVE DISEASES, MOLECULAR-MECHANISMS, IONIZING-RADIATION, GROWTH ARREST, CELLS, MICROGLIA, ASTROCYTES