Cellular plasticity: the good, the bad, and the ugly? Microenvironmental influences on progenitor cell therapyMoonen, J-R. A. J., Harmsen, M. C. & Krenning, G., Mar-2012, In : Canadian journal of physiology and pharmacology. 90, 3, p. 275-285 11 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Progenitor cell based therapies have emerged for the treatment of ischemic cardiovascular diseases where there is insufficient endogenous repair. However, clinical success has been limited, which challenges the original premise that transplanted progenitor cells would orchestrate repair. In this review, we discuss the basics of endothelial progenitor cell therapy and describe how microenvironmental changes (i.e., trophic and mechano-structural factors) in the damaged myocardium influence progenitor cell plasticity and hamper beneficial therapeutic outcome. Further understanding of these microenvironmental clues will enable optimization of cell therapy at all levels. We discuss current concepts and provide future perspectives for the enhancement of progenitor cell therapy, and merge these advances into a combined approach for ischemic tissue repair.
|Number of pages||11|
|Journal||Canadian journal of physiology and pharmacology|
|Publication status||Published - Mar-2012|
- cardiovascular disease, plasticity, cell therapy, endothelial progenitor cell, microenvironment, inflammation, endothelial-mesenchymal transition, mechanotransduction, fluid shear stress, cyclic strain, SMOOTH-MUSCLE-CELLS, MESENCHYMAL STEM-CELLS, FLUID SHEAR-STRESS, GROWTH-FACTOR-BETA, MURINE MYOCARDIAL-INFARCTION, VASCULAR ENDOTHELIAL-CELLS, IMPROVES CARDIAC-FUNCTION, ZINC-FINGER PROTEIN, C-REACTIVE PROTEIN, HEART-FAILURE