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Cellular Localization and Processing of Primary Transcripts of Exonic MicroRNAs

Slezak-Prochazka, I., Kluiver, J., de Jong, D., Kortman, G., Halsema, N., Poppema, S., Kroesen, B-J. & van den Berg, A., 20-Sep-2013, In : PLoS ONE. 8, 9, 11 p., e76647.

Research output: Contribution to journalArticleAcademicpeer-review

Processing of miRNAs occurs simultaneous with the transcription and splicing of their primary transcripts. For the small subset of exonic miRNAs it is unclear if the unspliced and/or spliced transcripts are used for miRNA biogenesis. We assessed endogenous levels and cellular location of primary transcripts of three exonic miRNAs. The ratio between unspliced and spliced transcripts varied markedly, i.e. >1 for BIC,

Original languageEnglish
Article numbere76647
Number of pages11
JournalPLoS ONE
Volume8
Issue number9
Publication statusPublished - 20-Sep-2013

    Keywords

  • MICROPROCESSOR COMPLEX, HODGKIN LYMPHOMA, BURKITT-LYMPHOMA, MESSENGER-RNAS, NONCODING RNA, CELLS, EXPRESSION, LINES, SITES, GENE

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