Cellular immune regulation in the pathogenesis of ANCA-associated vasculitidesvon Borstel, A., Sanders, J-S., Rutgers, A., Stegeman, C. A., Heeringa, P. & Abdulahad, W. H., Apr-2018, In : Autoimmunity reviews. 17, 4, p. 413-421 9 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are systemic autoimmune diseases characterized by necrotizing inflammation of small- to medium-sized blood vessels, affecting primarily the lungs and kidneys. Both animal and human studies show that the balance between inflammatory- and regulatory T and B cells determines the AAV disease pathogenesis. Recent evidence shows malfunctioning of the regulatory lymphocyte compartment in AAV. In this review we summarize the immune regulatory properties of both T- and B cells in patients with AAV and discuss how aberrations herein might contribute to the disease pathogenesis.
|Number of pages||9|
|Early online date||9-Feb-2018|
|Publication status||Published - Apr-2018|
- Vasculitides, ANCA, T regulatory cells, B regulatory cells