Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides

von Borstel, A., Sanders, J-S., Rutgers, A., Stegeman, C. A., Heeringa, P. & Abdulahad, W. H., Apr-2018, In : Autoimmunity reviews. 17, 4, p. 413-421 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are systemic autoimmune diseases characterized by necrotizing inflammation of small- to medium-sized blood vessels, affecting primarily the lungs and kidneys. Both animal and human studies show that the balance between inflammatory- and regulatory T and B cells determines the AAV disease pathogenesis. Recent evidence shows malfunctioning of the regulatory lymphocyte compartment in AAV. In this review we summarize the immune regulatory properties of both T- and B cells in patients with AAV and discuss how aberrations herein might contribute to the disease pathogenesis.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalAutoimmunity reviews
Issue number4
Early online date9-Feb-2018
Publication statusPublished - Apr-2018


  • Vasculitides, ANCA, T regulatory cells, B regulatory cells

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