Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

Demaria, M., Desprez, P. Y., Campisi, J. & Velarde, M. C., Jul-2015, In : Journal of Investigative Dermatology. 135, 7, p. 1722-6 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.

Original languageEnglish
Pages (from-to)1722-6
Number of pages5
JournalJournal of Investigative Dermatology
Issue number7
Publication statusPublished - Jul-2015
Externally publishedYes


  • Animals, Cell Aging, Cell Differentiation, Cell Division, Epidermis, Female, Fibroblasts, Homeostasis, Humans, Male, Mice, Sensitivity and Specificity, Skin, Skin Aging, Wound Healing

ID: 26937544