Publication

CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

von Borstel, A., Land, J., Abdulahad, W. H., Rutgers, A., Stegeman, C. A., Diepstra, A., Heeringa, P. & Sanders, J. S., 24-Sep-2019, In : Frontiers in Immunology. 10, 10 p., 2221.

Research output: Contribution to journalArticleAcademicpeer-review

APA

von Borstel, A., Land, J., Abdulahad, W. H., Rutgers, A., Stegeman, C. A., Diepstra, A., ... Sanders, J. S. (2019). CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients. Frontiers in Immunology, 10, [2221]. https://doi.org/10.3389/fimmu.2019.02221

Author

von Borstel, Anouk ; Land, Judith ; Abdulahad, Wayel H ; Rutgers, Abraham ; Stegeman, Coen A ; Diepstra, Arjan ; Heeringa, Peter ; Sanders, Jan Stephan. / CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients. In: Frontiers in Immunology. 2019 ; Vol. 10.

Harvard

von Borstel, A, Land, J, Abdulahad, WH, Rutgers, A, Stegeman, CA, Diepstra, A, Heeringa, P & Sanders, JS 2019, 'CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients', Frontiers in Immunology, vol. 10, 2221. https://doi.org/10.3389/fimmu.2019.02221

Standard

CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients. / von Borstel, Anouk; Land, Judith; Abdulahad, Wayel H; Rutgers, Abraham; Stegeman, Coen A; Diepstra, Arjan; Heeringa, Peter; Sanders, Jan Stephan.

In: Frontiers in Immunology, Vol. 10, 2221, 24.09.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

von Borstel A, Land J, Abdulahad WH, Rutgers A, Stegeman CA, Diepstra A et al. CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients. Frontiers in Immunology. 2019 Sep 24;10. 2221. https://doi.org/10.3389/fimmu.2019.02221


BibTeX

@article{c655afa2500c460595bc4ccb390de1ba,
title = "CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients",
abstract = "Background: Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies.Methods: Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27(+)CD38(hi) B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement.Results: Within 1.6 years, 30{\%} of patients experienced a relapse. The CD27(+)CD38(hi) B cell frequency at the time of inclusion was increased in F-R (median: 2.39{\%}) compared to N-R patients (median: 1.03{\%}; p = 0.0025) and a trend was found compared with the HCs (median: 1.33{\%}; p = 0.08). This increased CD27(+)CD38(hi) B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7{\%} of patients with an increased CD27(+)CD38(hi) B cell frequency (>= 2.39{\%}) relapsed during follow-up compared to 19.7{\%} of patients with a CD27(+)CD38(hi) B cell frequency ofConclusions: Our data suggests that having an increased frequency of circulating CD27(+)CD38(hi) B cells during remission is related to a higher relapse risk in GPA patients, and thereforemight be a potentialmarker to identify those GPA patients at risk for relapse.",
keywords = "vasculitis, granulomatosis with polyangiitis, ANCA, B cells, relapse, CYTOPLASMIC AUTOANTIBODIES, WEGENERS-GRANULOMATOSIS, PLASMA-CELLS, VASCULITIS, CYCLOPHOSPHAMIDE, DIFFERENTIATION, SPECIFICITY, ACTIVATION, RITUXIMAB, PROTEIN",
author = "{von Borstel}, Anouk and Judith Land and Abdulahad, {Wayel H} and Abraham Rutgers and Stegeman, {Coen A} and Arjan Diepstra and Peter Heeringa and Sanders, {Jan Stephan}",
note = "Copyright {\circledC} 2019 von Borstel, Land, Abdulahad, Rutgers, Stegeman, Diepstra, Heeringa and Sanders.",
year = "2019",
month = "9",
day = "24",
doi = "10.3389/fimmu.2019.02221",
language = "English",
volume = "10",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media SA",

}

RIS

TY - JOUR

T1 - CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

AU - von Borstel, Anouk

AU - Land, Judith

AU - Abdulahad, Wayel H

AU - Rutgers, Abraham

AU - Stegeman, Coen A

AU - Diepstra, Arjan

AU - Heeringa, Peter

AU - Sanders, Jan Stephan

N1 - Copyright © 2019 von Borstel, Land, Abdulahad, Rutgers, Stegeman, Diepstra, Heeringa and Sanders.

PY - 2019/9/24

Y1 - 2019/9/24

N2 - Background: Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies.Methods: Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27(+)CD38(hi) B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement.Results: Within 1.6 years, 30% of patients experienced a relapse. The CD27(+)CD38(hi) B cell frequency at the time of inclusion was increased in F-R (median: 2.39%) compared to N-R patients (median: 1.03%; p = 0.0025) and a trend was found compared with the HCs (median: 1.33%; p = 0.08). This increased CD27(+)CD38(hi) B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7% of patients with an increased CD27(+)CD38(hi) B cell frequency (>= 2.39%) relapsed during follow-up compared to 19.7% of patients with a CD27(+)CD38(hi) B cell frequency ofConclusions: Our data suggests that having an increased frequency of circulating CD27(+)CD38(hi) B cells during remission is related to a higher relapse risk in GPA patients, and thereforemight be a potentialmarker to identify those GPA patients at risk for relapse.

AB - Background: Granulomatosis with polyangiitis (GPA) patients are prone to disease relapses. We aimed to determine whether GPA patients at risk for relapse can be identified by differences in B cell subset frequencies.Methods: Eighty-five GPA patients were monitored for a median period of 3.1 years (range: 0.1-6.3). Circulating B cell subset frequencies were analyzed by flow cytometry determining the expression of CD19, CD38, and CD27. B cell subset frequencies at the time of inclusion of future-relapsing (F-R) and non-relapsing (N-R) patients were compared and related to relapse-free survival. Additionally, CD27(+)CD38(hi) B cells were assessed in urine and kidney biopsies from active anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV) patients with renal involvement.Results: Within 1.6 years, 30% of patients experienced a relapse. The CD27(+)CD38(hi) B cell frequency at the time of inclusion was increased in F-R (median: 2.39%) compared to N-R patients (median: 1.03%; p = 0.0025) and a trend was found compared with the HCs (median: 1.33%; p = 0.08). This increased CD27(+)CD38(hi) B cell frequency at inclusion was correlated to decreased relapse-free survival in GPA patients. In addition, 74.7% of patients with an increased CD27(+)CD38(hi) B cell frequency (>= 2.39%) relapsed during follow-up compared to 19.7% of patients with a CD27(+)CD38(hi) B cell frequency ofConclusions: Our data suggests that having an increased frequency of circulating CD27(+)CD38(hi) B cells during remission is related to a higher relapse risk in GPA patients, and thereforemight be a potentialmarker to identify those GPA patients at risk for relapse.

KW - vasculitis

KW - granulomatosis with polyangiitis

KW - ANCA

KW - B cells

KW - relapse

KW - CYTOPLASMIC AUTOANTIBODIES

KW - WEGENERS-GRANULOMATOSIS

KW - PLASMA-CELLS

KW - VASCULITIS

KW - CYCLOPHOSPHAMIDE

KW - DIFFERENTIATION

KW - SPECIFICITY

KW - ACTIVATION

KW - RITUXIMAB

KW - PROTEIN

U2 - 10.3389/fimmu.2019.02221

DO - 10.3389/fimmu.2019.02221

M3 - Article

C2 - 31608054

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2221

ER -

ID: 98950162