Publication

Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

Maity, S., Ottelé, J., Santiago, G. M., Frederix, P. W. J. M., Kroon, P., Markovitch, O., Stuart, M. C. A., Marrink, S. J., Otto, S. & Roos, W. H., 12-Aug-2020, In : Journal of the American Chemical Society. 142, 32, p. 13709-13717 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Maity, S., Ottelé, J., Santiago, G. M., Frederix, P. W. J. M., Kroon, P., Markovitch, O., Stuart, M. C. A., Marrink, S. J., Otto, S., & Roos, W. H. (2020). Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. Journal of the American Chemical Society, 142(32), 13709-13717. https://doi.org/10.1021/jacs.0c02635

Author

Maity, Sourav ; Ottelé, Jim ; Santiago, Guillermo Monreal ; Frederix, Pim W J M ; Kroon, Peter ; Markovitch, Omer ; Stuart, Marc C A ; Marrink, Siewert J ; Otto, Sijbren ; Roos, Wouter H. / Caught in the Act : Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. In: Journal of the American Chemical Society. 2020 ; Vol. 142, No. 32. pp. 13709-13717.

Harvard

Maity, S, Ottelé, J, Santiago, GM, Frederix, PWJM, Kroon, P, Markovitch, O, Stuart, MCA, Marrink, SJ, Otto, S & Roos, WH 2020, 'Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization', Journal of the American Chemical Society, vol. 142, no. 32, pp. 13709-13717. https://doi.org/10.1021/jacs.0c02635

Standard

Caught in the Act : Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. / Maity, Sourav; Ottelé, Jim; Santiago, Guillermo Monreal; Frederix, Pim W J M; Kroon, Peter; Markovitch, Omer; Stuart, Marc C A; Marrink, Siewert J; Otto, Sijbren; Roos, Wouter H.

In: Journal of the American Chemical Society, Vol. 142, No. 32, 12.08.2020, p. 13709-13717.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Maity S, Ottelé J, Santiago GM, Frederix PWJM, Kroon P, Markovitch O et al. Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization. Journal of the American Chemical Society. 2020 Aug 12;142(32):13709-13717. https://doi.org/10.1021/jacs.0c02635


BibTeX

@article{76bf8db58715489ab069e4ec2462ae66,
title = "Caught in the Act: Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization",
abstract = "Self-assembly features prominently in fields ranging from materials science to biophysical chemistry. Assembly pathways, often passing through transient intermediates, can control the outcome of assembly processes. Yet, the mechanisms of self-assembly remain largely obscure due to a lack of experimental tools for probing these pathways at the molecular level. Here, the self-assembly of self-replicators into fibers is visualized in real-time by high-speed atomic force microscopy (HS-AFM). Fiber growth requires the conversion of precursor molecules into six-membered macrocycles, which constitute the fibers. HS-AFM experiments, supported by molecular dynamics simulations, revealed that aggregates of precursor molecules accumulate at the sides of the fibers, which then diffuse to the fiber ends where growth takes place. This mechanism of precursor reservoir formation, followed by one-dimensional diffusion, which guides the precursor molecules to the sites of growth, reduces the entropic penalty associated with colocalizing precursors and growth sites and constitutes a new mechanism for supramolecular polymerization.",
keywords = "MOLECULAR-DYNAMICS, FORCE-FIELD, SYSTEMS, PARAMETERS",
author = "Sourav Maity and Jim Ottel{\'e} and Santiago, {Guillermo Monreal} and Frederix, {Pim W J M} and Peter Kroon and Omer Markovitch and Stuart, {Marc C A} and Marrink, {Siewert J} and Sijbren Otto and Roos, {Wouter H}",
year = "2020",
month = aug,
day = "12",
doi = "10.1021/jacs.0c02635",
language = "English",
volume = "142",
pages = "13709--13717",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "32",

}

RIS

TY - JOUR

T1 - Caught in the Act

T2 - Mechanistic Insight into Supramolecular Polymerization-Driven Self-Replication from Real-Time Visualization

AU - Maity, Sourav

AU - Ottelé, Jim

AU - Santiago, Guillermo Monreal

AU - Frederix, Pim W J M

AU - Kroon, Peter

AU - Markovitch, Omer

AU - Stuart, Marc C A

AU - Marrink, Siewert J

AU - Otto, Sijbren

AU - Roos, Wouter H

PY - 2020/8/12

Y1 - 2020/8/12

N2 - Self-assembly features prominently in fields ranging from materials science to biophysical chemistry. Assembly pathways, often passing through transient intermediates, can control the outcome of assembly processes. Yet, the mechanisms of self-assembly remain largely obscure due to a lack of experimental tools for probing these pathways at the molecular level. Here, the self-assembly of self-replicators into fibers is visualized in real-time by high-speed atomic force microscopy (HS-AFM). Fiber growth requires the conversion of precursor molecules into six-membered macrocycles, which constitute the fibers. HS-AFM experiments, supported by molecular dynamics simulations, revealed that aggregates of precursor molecules accumulate at the sides of the fibers, which then diffuse to the fiber ends where growth takes place. This mechanism of precursor reservoir formation, followed by one-dimensional diffusion, which guides the precursor molecules to the sites of growth, reduces the entropic penalty associated with colocalizing precursors and growth sites and constitutes a new mechanism for supramolecular polymerization.

AB - Self-assembly features prominently in fields ranging from materials science to biophysical chemistry. Assembly pathways, often passing through transient intermediates, can control the outcome of assembly processes. Yet, the mechanisms of self-assembly remain largely obscure due to a lack of experimental tools for probing these pathways at the molecular level. Here, the self-assembly of self-replicators into fibers is visualized in real-time by high-speed atomic force microscopy (HS-AFM). Fiber growth requires the conversion of precursor molecules into six-membered macrocycles, which constitute the fibers. HS-AFM experiments, supported by molecular dynamics simulations, revealed that aggregates of precursor molecules accumulate at the sides of the fibers, which then diffuse to the fiber ends where growth takes place. This mechanism of precursor reservoir formation, followed by one-dimensional diffusion, which guides the precursor molecules to the sites of growth, reduces the entropic penalty associated with colocalizing precursors and growth sites and constitutes a new mechanism for supramolecular polymerization.

KW - MOLECULAR-DYNAMICS

KW - FORCE-FIELD

KW - SYSTEMS

KW - PARAMETERS

U2 - 10.1021/jacs.0c02635

DO - 10.1021/jacs.0c02635

M3 - Article

C2 - 32786814

VL - 142

SP - 13709

EP - 13717

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 32

ER -

ID: 131519096