Publication

Cardiac Function After Radiation Therapy for Breast Cancer

van den Bogaard, V. A. B., van Luijk, P., Hummel, Y. M., van der Meer, P., Schuit, E., Boerman, L. M., Maas, S. W. M. C., Nauta, J. F., Steggink, L. C., Gietema, J. A., de Bock, G. H., Berendsen, A. J., Smit, W. G. J. M., Sijtsema, N. M., Kierkels, R. G. J., Langendijk, J. A., Crijns, A. P. G. & Maduro, J. H., 1-Jun-2019, In : International Journal of Radiation Oncology, Biology, Physics. 104, 2, p. 392-400 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van den Bogaard, V. A. B., van Luijk, P., Hummel, Y. M., van der Meer, P., Schuit, E., Boerman, L. M., ... Maduro, J. H. (2019). Cardiac Function After Radiation Therapy for Breast Cancer. International Journal of Radiation Oncology, Biology, Physics, 104(2), 392-400. https://doi.org/10.1016/j.ijrobp.2019.02.003

Author

van den Bogaard, Veerle A. B. ; van Luijk, Peter ; Hummel, Yoran M. ; van der Meer, Peter ; Schuit, Ewoud ; Boerman, Liselotte M. ; Maas, Saskia W. M. C. ; Nauta, Jan F. ; Steggink, Lars C. ; Gietema, Jourik A. ; de Bock, Geertruida H. ; Berendsen, Annette J. ; Smit, Wilma G. J. M. ; Sijtsema, Nanna M. ; Kierkels, Roel G. J. ; Langendijk, Johannes A. ; Crijns, Anne P. G. ; Maduro, John H. / Cardiac Function After Radiation Therapy for Breast Cancer. In: International Journal of Radiation Oncology, Biology, Physics. 2019 ; Vol. 104, No. 2. pp. 392-400.

Harvard

van den Bogaard, VAB, van Luijk, P, Hummel, YM, van der Meer, P, Schuit, E, Boerman, LM, Maas, SWMC, Nauta, JF, Steggink, LC, Gietema, JA, de Bock, GH, Berendsen, AJ, Smit, WGJM, Sijtsema, NM, Kierkels, RGJ, Langendijk, JA, Crijns, APG & Maduro, JH 2019, 'Cardiac Function After Radiation Therapy for Breast Cancer' International Journal of Radiation Oncology, Biology, Physics, vol. 104, no. 2, pp. 392-400. https://doi.org/10.1016/j.ijrobp.2019.02.003

Standard

Cardiac Function After Radiation Therapy for Breast Cancer. / van den Bogaard, Veerle A. B.; van Luijk, Peter; Hummel, Yoran M.; van der Meer, Peter; Schuit, Ewoud; Boerman, Liselotte M.; Maas, Saskia W. M. C.; Nauta, Jan F.; Steggink, Lars C.; Gietema, Jourik A.; de Bock, Geertruida H.; Berendsen, Annette J.; Smit, Wilma G. J. M.; Sijtsema, Nanna M.; Kierkels, Roel G. J.; Langendijk, Johannes A.; Crijns, Anne P. G.; Maduro, John H.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 104, No. 2, 01.06.2019, p. 392-400.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van den Bogaard VAB, van Luijk P, Hummel YM, van der Meer P, Schuit E, Boerman LM et al. Cardiac Function After Radiation Therapy for Breast Cancer. International Journal of Radiation Oncology, Biology, Physics. 2019 Jun 1;104(2):392-400. https://doi.org/10.1016/j.ijrobp.2019.02.003


BibTeX

@article{e125ec9338fd4c3daa3edd67e93a4e58,
title = "Cardiac Function After Radiation Therapy for Breast Cancer",
abstract = "Purpose: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiation therapy (RT).Methods and Materials: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricular ejection fraction (LVEF) (n = 107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n = 52). LV diastolic dysfunction (n = 109) was defined by e' at the lateral and septal region, which represents the relaxation velocity of the myocardium. The individual calculated RT dose parameters of the LV and coronary arteries were collected from 3-dimensional computed tomographyebased planning data. Univariable and multivariable analysis using forward selection was performed to identify the best predictors of cardiac function. Robustness of selection was assessed using bootstrapping. The resulting multivariable linear regression model was presented for the endpoints of systolic and diastolic function.Results: The median time between BC diagnosis and echocardiography was 7 years. No relation between RT dose parameters and LVEF was found. In the multivariable analysis for the endpoint GLS of the LV, the maximum dose to the left main coronary artery was most often selected across bootstrap samples. For decreased diastolic function, the most often selected model across bootstrap samples included age at time of BC diagnosis and hypertension at baseline. Cardiac dose-volume histogram parameters were less frequently selected for this endpoint.Conclusions: This study shows an association between individual cardiac dose distributions and GLS of the LV after RT for BC. No relation between RT dose parameters and LVEF was found. Diastolic function was most associated with age and hypertension at time of BC diagnosis. Further research is needed to make definitive conclusions. (C) 2019 Elsevier Inc. All rights reserved.",
keywords = "GLOBAL LONGITUDINAL STRAIN, ISCHEMIC-HEART-DISEASE, EJECTION FRACTION, RADIOTHERAPY, WOMEN, RECOMMENDATIONS, CARDIOTOXICITY, COMPLICATIONS, MORBIDITY, EXPOSURE",
author = "{van den Bogaard}, {Veerle A. B.} and {van Luijk}, Peter and Hummel, {Yoran M.} and {van der Meer}, Peter and Ewoud Schuit and Boerman, {Liselotte M.} and Maas, {Saskia W. M. C.} and Nauta, {Jan F.} and Steggink, {Lars C.} and Gietema, {Jourik A.} and {de Bock}, {Geertruida H.} and Berendsen, {Annette J.} and Smit, {Wilma G. J. M.} and Sijtsema, {Nanna M.} and Kierkels, {Roel G. J.} and Langendijk, {Johannes A.} and Crijns, {Anne P. G.} and Maduro, {John H.}",
note = "Copyright {\circledC} 2019. Published by Elsevier Inc.",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.ijrobp.2019.02.003",
language = "English",
volume = "104",
pages = "392--400",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "ELSEVIER SCIENCE INC",
number = "2",

}

RIS

TY - JOUR

T1 - Cardiac Function After Radiation Therapy for Breast Cancer

AU - van den Bogaard, Veerle A. B.

AU - van Luijk, Peter

AU - Hummel, Yoran M.

AU - van der Meer, Peter

AU - Schuit, Ewoud

AU - Boerman, Liselotte M.

AU - Maas, Saskia W. M. C.

AU - Nauta, Jan F.

AU - Steggink, Lars C.

AU - Gietema, Jourik A.

AU - de Bock, Geertruida H.

AU - Berendsen, Annette J.

AU - Smit, Wilma G. J. M.

AU - Sijtsema, Nanna M.

AU - Kierkels, Roel G. J.

AU - Langendijk, Johannes A.

AU - Crijns, Anne P. G.

AU - Maduro, John H.

N1 - Copyright © 2019. Published by Elsevier Inc.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Purpose: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiation therapy (RT).Methods and Materials: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricular ejection fraction (LVEF) (n = 107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n = 52). LV diastolic dysfunction (n = 109) was defined by e' at the lateral and septal region, which represents the relaxation velocity of the myocardium. The individual calculated RT dose parameters of the LV and coronary arteries were collected from 3-dimensional computed tomographyebased planning data. Univariable and multivariable analysis using forward selection was performed to identify the best predictors of cardiac function. Robustness of selection was assessed using bootstrapping. The resulting multivariable linear regression model was presented for the endpoints of systolic and diastolic function.Results: The median time between BC diagnosis and echocardiography was 7 years. No relation between RT dose parameters and LVEF was found. In the multivariable analysis for the endpoint GLS of the LV, the maximum dose to the left main coronary artery was most often selected across bootstrap samples. For decreased diastolic function, the most often selected model across bootstrap samples included age at time of BC diagnosis and hypertension at baseline. Cardiac dose-volume histogram parameters were less frequently selected for this endpoint.Conclusions: This study shows an association between individual cardiac dose distributions and GLS of the LV after RT for BC. No relation between RT dose parameters and LVEF was found. Diastolic function was most associated with age and hypertension at time of BC diagnosis. Further research is needed to make definitive conclusions. (C) 2019 Elsevier Inc. All rights reserved.

AB - Purpose: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiation therapy (RT).Methods and Materials: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Systolic function was assessed with the left ventricular ejection fraction (LVEF) (n = 107) and the global longitudinal strain (GLS) of the left ventricle (LV) (n = 52). LV diastolic dysfunction (n = 109) was defined by e' at the lateral and septal region, which represents the relaxation velocity of the myocardium. The individual calculated RT dose parameters of the LV and coronary arteries were collected from 3-dimensional computed tomographyebased planning data. Univariable and multivariable analysis using forward selection was performed to identify the best predictors of cardiac function. Robustness of selection was assessed using bootstrapping. The resulting multivariable linear regression model was presented for the endpoints of systolic and diastolic function.Results: The median time between BC diagnosis and echocardiography was 7 years. No relation between RT dose parameters and LVEF was found. In the multivariable analysis for the endpoint GLS of the LV, the maximum dose to the left main coronary artery was most often selected across bootstrap samples. For decreased diastolic function, the most often selected model across bootstrap samples included age at time of BC diagnosis and hypertension at baseline. Cardiac dose-volume histogram parameters were less frequently selected for this endpoint.Conclusions: This study shows an association between individual cardiac dose distributions and GLS of the LV after RT for BC. No relation between RT dose parameters and LVEF was found. Diastolic function was most associated with age and hypertension at time of BC diagnosis. Further research is needed to make definitive conclusions. (C) 2019 Elsevier Inc. All rights reserved.

KW - GLOBAL LONGITUDINAL STRAIN

KW - ISCHEMIC-HEART-DISEASE

KW - EJECTION FRACTION

KW - RADIOTHERAPY

KW - WOMEN

KW - RECOMMENDATIONS

KW - CARDIOTOXICITY

KW - COMPLICATIONS

KW - MORBIDITY

KW - EXPOSURE

U2 - 10.1016/j.ijrobp.2019.02.003

DO - 10.1016/j.ijrobp.2019.02.003

M3 - Article

VL - 104

SP - 392

EP - 400

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 2

ER -

ID: 76011514