Captopril impairs the vascular smooth muscle contraction mediated by postsynaptic α2-adrenoceptors in the pithed rat

De Jonge, A., Wilffert, B. & Kalkman, H. O., 1-Oct-1981, In : European Journal of Pharmacology. 74, 4, p. 385-386 2 p.

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Since two different types of α-adrenoceptors (α1- and α2-) subserve vasoconstriction in pithed rats and noradrenaline behaves as a non-selective agonist of both receptors (for review see Timmerman and van Zwieten, 1981), we have investigated this interaction between noradrenaline and captopril in more detail to identify the class of α-adrenoceptor involved. This study confirms the findings reported recently (Antonaccio and Kerwin, 1981; Clough et al., 1981) that captopril inhibits postjunctional vasocontrictor responses to noradrenaline in pithed rats. However, captopril interfered with the vasoconstriction elicited by noradrenaline only in those animals in which the vascular postsynaptic α2-adrenoceptor system could be triggered (saline-and prazosin-treated rats). Captopril was without effect after removal of the contribution of post-synaptic α2-adrenoceptor stimulation to the in vivo vascular smooth muscle contraction due to (-)-noradrenaline (rauwolscine-treated rats). These results indicate that captopril selectively impairs the vasoconstriction subserved in vivo by postjunctinal α2-adrenoceptors. The vasoconstrictor process initiated by α1-adrenoceptor activation is not affected by captopril.
Original languageEnglish
Pages (from-to)385-386
Number of pages2
JournalEuropean Journal of Pharmacology
Issue number4
Publication statusPublished - 1-Oct-1981


  • alpha adrenergic receptor, alpha adrenergic receptor stimulating agent, captopril, noradrenalin, postsynaptic receptor, prazosin, rauwolscine, sotalol, animal experiment, blood pressure, cardiovascular system, central nervous system, drug response, endocrine system, kidney, peripheral vascular system, rat, renin angiotensin aldosterone system, smooth muscle, smooth muscle contractility, spinal animal, vascular smooth muscle

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