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Cancer treatment induced metabolic syndrome: Improving outcome with lifestyle

Westerink, M. D. N. L., Nuver, J., Lefrandt, J. D., Vrieling, A. H., Gietema, J. A. & Walenkamp, A. M. E., Dec-2016, In : Critical Reviews in Oncology/Hematology. 108, p. 128-136 9 p.

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Increasing numbers of long-term cancer survivors face important treatment related adverse effects. Cancer treatment induced metabolic syndrome (CTIMetS) is an especially prevalent and harmful condition. The aetiology of CTIMetS likely differs from metabolic syndrome in the general population, but effective treatment and prevention methods are probably similar. In this review, we summarize the potential mechanisms leading to the development of CTIMetS after various types of cancer treatment. Furthermore, we propose a safe and accessible method to treat or prevent CTIMetS through lifestyle change. In particular, we suggest that a lifestyle intervention and optimization of energy balance can prevent or mitigate the development of CTIMetS, which may contribute to optimal survivorship care. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)128-136
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume108
Publication statusPublished - Dec-2016

    Keywords

  • Metabolic syndrome X, Cancer, Survivors, Exercise, Life style, Cancer treatment protocols, ANDROGEN-DEPRIVATION THERAPY, LONG-TERM SURVIVORS, ACUTE LYMPHOBLASTIC-LEUKEMIA, EARLY BREAST-CANCER, CARDIOVASCULAR-DISEASE, PROSTATE-CANCER, TESTICULAR CANCER, CARDIORESPIRATORY FITNESS, POSTMENOPAUSAL WOMEN, BODY-COMPOSITION

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