Publication

Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?

Nawijn, M. C. & Timens, W., Jul-2020, In : Molecular Systems Biology. 16, 7, p. e9841 3 p., e9841.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Nawijn, M. C., & Timens, W. (2020). Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? Molecular Systems Biology, 16(7), e9841. [e9841]. https://doi.org/10.15252/msb.20209841

Author

Nawijn, Martijn C ; Timens, Wim. / Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?. In: Molecular Systems Biology. 2020 ; Vol. 16, No. 7. pp. e9841.

Harvard

Nawijn, MC & Timens, W 2020, 'Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?', Molecular Systems Biology, vol. 16, no. 7, e9841, pp. e9841. https://doi.org/10.15252/msb.20209841

Standard

Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? / Nawijn, Martijn C; Timens, Wim.

In: Molecular Systems Biology, Vol. 16, No. 7, e9841, 07.2020, p. e9841.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Nawijn MC, Timens W. Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19? Molecular Systems Biology. 2020 Jul;16(7):e9841. e9841. https://doi.org/10.15252/msb.20209841


BibTeX

@article{6e364d92da214893a3b984ab562fa17e,
title = "Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?",
abstract = "Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS-CoV-2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels-if at all-in respiratory epithelial cells. Severe COVID-19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID-19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?",
author = "Nawijn, {Martijn C} and Wim Timens",
note = "{\textcopyright} 2020 The Authors. Published under the terms of the CC BY 4.0 license.",
year = "2020",
month = jul,
doi = "10.15252/msb.20209841",
language = "English",
volume = "16",
pages = "e9841",
journal = "Molecular Systems Biology",
issn = "1744-4292",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?

AU - Nawijn, Martijn C

AU - Timens, Wim

N1 - © 2020 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2020/7

Y1 - 2020/7

N2 - Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS-CoV-2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels-if at all-in respiratory epithelial cells. Severe COVID-19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID-19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?

AB - Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) leads to coronavirus disease 2019 (COVID-19), which poses an unprecedented worldwide health crisis, and has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. The angiotensin converting enzyme 2 (ACE2) has been suggested to be the key protein used by SARS-CoV-2 for host cell entry. In their recent work, Lindskog and colleagues (Hikmet et al, 2020) report that ACE2 is expressed at very low protein levels-if at all-in respiratory epithelial cells. Severe COVID-19, however, is characterized by acute respiratory distress syndrome and extensive damage to the alveoli in the lung parenchyma. Then, what is the role of the airway epithelium in the early stages of COVID-19, and which cells need to be studied to characterize the biological mechanisms responsible for the progression to severe disease after initial infection by the novel coronavirus?

U2 - 10.15252/msb.20209841

DO - 10.15252/msb.20209841

M3 - Article

C2 - 32715628

VL - 16

SP - e9841

JO - Molecular Systems Biology

JF - Molecular Systems Biology

SN - 1744-4292

IS - 7

M1 - e9841

ER -

ID: 130524847