Publication

cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape

Wojtal, K. A., Hoekstra, D. & van IJzendoorn, S. C. D., Feb-2008, In : BioEssays. 30, 2, p. 146-155 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Cyclic adenosine monophosphate (cAMP) and cAMP-dependent protein kinase A (PKA) are evolutionary conserved molecules with a well-established position in the complex network of signal transduction pathways. cAMP/PKA-mediated signaling pathways are implicated in many biological processes that cooperate in organ development including the motility, survival, proliferation and differentiation of epithelial cells. Cell surface polarity, here defined as the anisotropic organisation of cellular membranes, is a critical parameter for most of these processes. Changes in the activity of cAMP/PKA elicit a variety of effects on intracellular membrane dynamics, including membrane sorting and trafficking. One of the most intriguing aspects of cAMP/PKA signaling is its evolutionary conserved abundance on the one hand and its precise spatial-temporal actions on the other. Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains.

Original languageEnglish
Pages (from-to)146-155
Number of pages10
JournalBioEssays
Volume30
Issue number2
Publication statusPublished - Feb-2008

    Keywords

  • RENAL PRINCIPAL CELLS, DROSOPHILA NEUROMUSCULAR-JUNCTIONS, POLARIZED SPHINGOLIPID TRANSPORT, MEDIATED SIGNAL-TRANSDUCTION, CANINE KIDNEY-CELLS, HEPG2 CELLS, SUBAPICAL COMPARTMENT, ANCHORING PROTEIN, ENDOPLASMIC-RETICULUM, CATALYTIC SUBUNIT

ID: 4677842