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cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs

Aktories, K., Gierschik, P., zu Heringdorf, D. M., Schmidt, M., Schultz, G. & Wieland, T., Aug-2019, In : Naunyn-Schmiedebergs Archives of Pharmacology. 392, 8, p. 887-911 25 p.

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  • cAMP guided his way: a life for G protein-mediated signaltransduction and molecular pharmacology—tribute to Karl H. Jakobs

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DOI

  • Klaus Aktories
  • Peter Gierschik
  • Dagmar Meyer zu Heringdorf
  • Martina Schmidt
  • Guenter Schultz
  • Thomas Wieland

Karl H. Jakobs, former editor-in-chief of Naunyn-Schmiedeberg's Archives of Pharmacology and renowned molecular pharmacologist, passed away in April 2018. In this article, his scientific achievements regarding G protein-mediated signal transduction and regulation of canonical pathways are summarized. Particularly, the discovery of inhibitory G proteins for adenylyl cyclase, methods for the analysis of receptor-G protein interactions, GTP supply by nucleoside diphosphate kinases, mechanisms in phospholipase C and phospholipase D activity regulation, as well as the development of the concept of sphingosine-1-phosphate as extra- and intracellular messenger will presented. His seminal scientific and methodological contributions are put in a general and timely perspective to display and honor his outstanding input to the current knowledge in molecular pharmacology.

Original languageEnglish
Pages (from-to)887-911
Number of pages25
JournalNaunyn-Schmiedebergs Archives of Pharmacology
Volume392
Issue number8
Publication statusPublished - Aug-2019

    Keywords

  • Heterotrimeric G protein, Low molecular mass GTP binding protein, Adenylyl cyclase, Phospholipase C, Phospholipase D, Calcium-dependent signaling, Sphingosine-1-phoshate, NUCLEOSIDE-DIPHOSPHATE KINASE, NUCLEOTIDE-EXCHANGE FACTOR, PHOSPHOLIPASE-C-EPSILON, MUSCARINIC ACETYLCHOLINE-RECEPTORS, BETA-ADRENERGIC-RECEPTOR, BINDING REGULATORY PROTEINS, PLATELET ADENYLATE-CYCLASE, HETEROTRIMERIC G-PROTEINS, ENERGY PHOSPHATE TRANSFER, DIFFICILE TOXIN-B

ID: 94402443