Publication

Calcium channels in the brain as targets for the calcium-channel modulators used in the treatment of neurological disorders

Peters, T., WILFFERT, B., VANHOUTTE, PM. & VANZWIETEN, PA., 1991, In : Journal of Cardiovascular Pharmacology. 18, p. S1-S5 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention.

Original languageEnglish
Pages (from-to)S1-S5
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Volume18
Publication statusPublished - 1991

    Keywords

  • NEURONS, CALCIUM CHANNELS, CALCIUM-CHANNEL MODULATORS, VERTEBRATE SENSORY NEURONS, VASCULAR SMOOTH-MUSCLE, HIPPOCAMPAL-NEURONS, ENTRY BLOCKERS, RAT, INVITRO, ANTAGONISTS, RELEASE, TRIAL, ELECTRORESPONSIVENESS

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