TY - JOUR

T1 - Caffeine, Diabetes, Cognition, and Dementia

AU - Biessels, Geert Jan

PY - 2010

Y1 - 2010

N2 - People with diabetes mellitus are at increased risk of cognitive dysfunction. This review explores the relation between caffeine intake, diabetes, cognition and dementia, focusing on type 2 diabetes (T2DM). Epidemiological studies on caffeine/coffee intake and T2DM risk are reviewed. Next, the impact of T2DM on cognition is addressed. Finally, the potential for caffeine to modulate the risk of cognitive decline in the context of diabetes is explored. The conclusion is that, although epidemiological studies indicate that coffee/caffeine consumption is associated with a decreased risk of T2DM and possibly also with a decreased dementia risk, we can at present not be certain that these associations are causal. For now, recommendations for coffee consumption in individuals with T2DM or pre-diabetic stages are therefore difficult to establish, but it should be acknowledged that caffeine does appear to have several properties that warrant further investigations in this field.

AB - People with diabetes mellitus are at increased risk of cognitive dysfunction. This review explores the relation between caffeine intake, diabetes, cognition and dementia, focusing on type 2 diabetes (T2DM). Epidemiological studies on caffeine/coffee intake and T2DM risk are reviewed. Next, the impact of T2DM on cognition is addressed. Finally, the potential for caffeine to modulate the risk of cognitive decline in the context of diabetes is explored. The conclusion is that, although epidemiological studies indicate that coffee/caffeine consumption is associated with a decreased risk of T2DM and possibly also with a decreased dementia risk, we can at present not be certain that these associations are causal. For now, recommendations for coffee consumption in individuals with T2DM or pre-diabetic stages are therefore difficult to establish, but it should be acknowledged that caffeine does appear to have several properties that warrant further investigations in this field.

KW - Alzheimer's disease

KW - caffeine

KW - coffee

KW - cognition

KW - dementia

KW - diabetes mellitus

KW - epidemiology

KW - insulin

KW - stroke

KW - vascular dementia

KW - HIPPOCAMPAL SYNAPTIC PLASTICITY

KW - ALZHEIMERS-DISEASE

KW - COFFEE CONSUMPTION

KW - INSULIN-RESISTANCE

KW - CARDIOVASCULAR-DISEASES

KW - METABOLIC SYNDROME

KW - GLUCOSE-TOLERANCE

KW - NERVOUS-SYSTEM

KW - OLDER PERSONS

KW - HEART-DISEASE

U2 - 10.3233/JAD-2010-091228

DO - 10.3233/JAD-2010-091228

M3 - Review article

VL - 20

SP - S143-S150

JO - Journal of Alzheimer’s Disease

JF - Journal of Alzheimer’s Disease

SN - 1875-8908

ER -