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Brain-based ranking of cognitive domains to predict schizophrenia

Karrer, T. M., Bassett, D. S., Derntl, B., Gruber, O., Aleman, A., Jardri, R., Laird, A. R., Fox, P. T., Eickhoff, S. B., Grisel, O., Varoquaux, G., Thirion, B. & Bzdok, D., 15-Oct-2019, In : Human brain mapping. 40, 15, 21 p.

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  • Brain‐based ranking of cognitive domains to predict schizophrenia

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DOI

  • Teresa M. Karrer
  • Danielle S. Bassett
  • Birgit Derntl
  • Oliver Gruber
  • Andre Aleman
  • Renaud Jardri
  • Angela R. Laird
  • Peter T. Fox
  • Simon B. Eickhoff
  • Olivier Grisel
  • Gael Varoquaux
  • Bertrand Thirion
  • Danilo Bzdok

Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions, we developed a data-driven machine-learning strategy and provide a proof of principle in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neurotopographical maps. We then examined how the ensuing meta-analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well-studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease relevant, including self-oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

Original languageEnglish
Number of pages21
JournalHuman brain mapping
Volume40
Issue number15
Publication statusPublished - 15-Oct-2019

    Keywords

  • BrainMap database, coordinate-based meta-analysis, ontology of the mind, pattern recognition, predictive analytics, statistical learning, AUDITORY VERBAL HALLUCINATIONS, LIKELIHOOD ESTIMATION, SOCIAL COGNITION, WORKING-MEMORY, GUSTATORY HALLUCINATIONS, COMPUTATIONAL PSYCHIATRY, FUNCTIONAL ARCHITECTURE, MISMATCH NEGATIVITY, METAANALYSIS, PERCEPTION

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