Publication

Blockade of the Kinin B1 Receptor Ameloriates Glomerulonephritis

Klein, J., Gonzalez, J., Decramer, S., Bandin, F., Neau, E., Salant, D. J., Heeringa, P., Pesquero, J-B., Schanstra, J-P. & Bascands, J-L., Jul-2010, In : Journal of the American Society of Nephrology. 21, 7, p. 1157-1164 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Julie Klein
  • Julien Gonzalez
  • Stephane Decramer
  • Flavio Bandin
  • Eric Neau
  • David J. Salant
  • Peter Heeringa
  • Joao-Bosco Pesquero
  • Joost-Peter Schanstra
  • Jean-Loup Bascands

Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. Delayed B1R blockade reduces renal inflammation in a model of unilateral ureteral obstruction, but whether B1R modulates the pathophysiology of glomerulonephritides is unknown. Here, we observed an association of B1R protein expression and inflammation, in both glomeruli and the renal interstitium, in biopsies of patients with glomerulonephritides, HenochSchonlein purpura nephropathy, and ANCA-associated vasculitis. In the nephrotoxic serum induced glomerulonephritis model, we observed upregulation of the B1R receptor; treatment with a B1R antagonist beginning 2 weeks after the onset of disease reduced both glomerular and tubular lesions and improved renal function. B1R blockade reduced renal chemokine expression and macrophage accumulation. Collectively, our data demonstrate that blockade of the kinin B1R has significant potential for the treatment of glomerulonephritis.

Original languageEnglish
Pages (from-to)1157-1164
Number of pages8
JournalJournal of the American Society of Nephrology
Volume21
Issue number7
Publication statusPublished - Jul-2010

    Keywords

  • ENDOTOXIN-INDUCED INFLAMMATION, BRADYKININ B-1 RECEPTOR, REDUCES RENAL FIBROSIS, HUMAN LUNG FIBROBLASTS, CRESCENTIC GLOMERULONEPHRITIS, GLOMERULAR INJURY, UP-REGULATION, MOUSE MODEL, IN-VIVO, ACTIVATION

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