Publication

BK Channels in the Vertebrate Inner Ear

Pyott, S. J. & Duncan, R. K., 2016, BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. Contet, C. (ed.). Academic Press, p. 369-399 31 p. (International Review of Neurobiology; vol. 128).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

APA

Pyott, S. J., & Duncan, R. K. (2016). BK Channels in the Vertebrate Inner Ear. In C. Contet (Ed.), BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128 (pp. 369-399). (International Review of Neurobiology; Vol. 128). Academic Press. https://doi.org/10.1016/bs.irn.2016.03.016

Author

Pyott, S. J. ; Duncan, R. K. / BK Channels in the Vertebrate Inner Ear. BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. editor / C Contet. Academic Press, 2016. pp. 369-399 (International Review of Neurobiology).

Harvard

Pyott, SJ & Duncan, RK 2016, BK Channels in the Vertebrate Inner Ear. in C Contet (ed.), BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. International Review of Neurobiology, vol. 128, Academic Press, pp. 369-399. https://doi.org/10.1016/bs.irn.2016.03.016

Standard

BK Channels in the Vertebrate Inner Ear. / Pyott, S. J.; Duncan, R. K.

BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. ed. / C Contet. Academic Press, 2016. p. 369-399 (International Review of Neurobiology; Vol. 128).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Vancouver

Pyott SJ, Duncan RK. BK Channels in the Vertebrate Inner Ear. In Contet C, editor, BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. Academic Press. 2016. p. 369-399. (International Review of Neurobiology). https://doi.org/10.1016/bs.irn.2016.03.016


BibTeX

@inbook{eb55a648031f4241a2b8c1ed88233cb2,
title = "BK Channels in the Vertebrate Inner Ear",
abstract = "The perception of complex acoustic stimuli begins with the deconstruction of sound into its frequency components. This spectral processing occurs first and foremost in the inner ear. In vertebrates, two very different strategies of frequency analysis have evolved. In nonmammalian vertebrates, the sensory hair cells of the inner ear are intrinsically electrically tuned to a narrow band of acoustic frequencies. This electrical tuning relies on the interplay between BK channels and voltage-gated calcium channels. Systematic variations in BK channel density and kinetics establish a gradient in electrical resonance that enables the coding of a broad range of acoustic frequencies. In contrast, mammalian hair cells are extrinsically tuned by mechanical properties of the cochlear duct. Even so, mammalian hair cells also express BK channels. These BK channels play critical roles in various aspects of mammalian auditory signaling, from developmental maturation to protection against acoustic trauma. This review summarizes the anatomical localization, biophysical properties, and functional contributions of BK channels in vertebrate inner ears. Areas of future research, based on an updated understanding of the biology of both BK channels and the inner ear, are also highlighted. Investigation of BK channels in the inner ear continues to provide fertile research grounds for examining both BK channel biophysics and the molecular mechanisms underlying signal processing in the auditory periphery.",
keywords = "OUTER HAIR-CELLS, ACTIVATED POTASSIUM CHANNELS, CA2+-ACTIVATED K+ CHANNELS, GUINEA-PIG COCHLEA, MEDIATE CHOLINERGIC INHIBITION, REGULATORY BETA-1 SUBUNIT, LARGE-CONDUCTANCE, SPLICE VARIANTS, BASILAR-MEMBRANE, MOUSE COCHLEA",
author = "Pyott, {S. J.} and Duncan, {R. K.}",
year = "2016",
doi = "10.1016/bs.irn.2016.03.016",
language = "English",
isbn = "978-0-12-803619-8",
series = "International Review of Neurobiology",
publisher = "Academic Press",
pages = "369--399",
editor = "C Contet",
booktitle = "BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128",

}

RIS

TY - CHAP

T1 - BK Channels in the Vertebrate Inner Ear

AU - Pyott, S. J.

AU - Duncan, R. K.

PY - 2016

Y1 - 2016

N2 - The perception of complex acoustic stimuli begins with the deconstruction of sound into its frequency components. This spectral processing occurs first and foremost in the inner ear. In vertebrates, two very different strategies of frequency analysis have evolved. In nonmammalian vertebrates, the sensory hair cells of the inner ear are intrinsically electrically tuned to a narrow band of acoustic frequencies. This electrical tuning relies on the interplay between BK channels and voltage-gated calcium channels. Systematic variations in BK channel density and kinetics establish a gradient in electrical resonance that enables the coding of a broad range of acoustic frequencies. In contrast, mammalian hair cells are extrinsically tuned by mechanical properties of the cochlear duct. Even so, mammalian hair cells also express BK channels. These BK channels play critical roles in various aspects of mammalian auditory signaling, from developmental maturation to protection against acoustic trauma. This review summarizes the anatomical localization, biophysical properties, and functional contributions of BK channels in vertebrate inner ears. Areas of future research, based on an updated understanding of the biology of both BK channels and the inner ear, are also highlighted. Investigation of BK channels in the inner ear continues to provide fertile research grounds for examining both BK channel biophysics and the molecular mechanisms underlying signal processing in the auditory periphery.

AB - The perception of complex acoustic stimuli begins with the deconstruction of sound into its frequency components. This spectral processing occurs first and foremost in the inner ear. In vertebrates, two very different strategies of frequency analysis have evolved. In nonmammalian vertebrates, the sensory hair cells of the inner ear are intrinsically electrically tuned to a narrow band of acoustic frequencies. This electrical tuning relies on the interplay between BK channels and voltage-gated calcium channels. Systematic variations in BK channel density and kinetics establish a gradient in electrical resonance that enables the coding of a broad range of acoustic frequencies. In contrast, mammalian hair cells are extrinsically tuned by mechanical properties of the cochlear duct. Even so, mammalian hair cells also express BK channels. These BK channels play critical roles in various aspects of mammalian auditory signaling, from developmental maturation to protection against acoustic trauma. This review summarizes the anatomical localization, biophysical properties, and functional contributions of BK channels in vertebrate inner ears. Areas of future research, based on an updated understanding of the biology of both BK channels and the inner ear, are also highlighted. Investigation of BK channels in the inner ear continues to provide fertile research grounds for examining both BK channel biophysics and the molecular mechanisms underlying signal processing in the auditory periphery.

KW - OUTER HAIR-CELLS

KW - ACTIVATED POTASSIUM CHANNELS

KW - CA2+-ACTIVATED K+ CHANNELS

KW - GUINEA-PIG COCHLEA

KW - MEDIATE CHOLINERGIC INHIBITION

KW - REGULATORY BETA-1 SUBUNIT

KW - LARGE-CONDUCTANCE

KW - SPLICE VARIANTS

KW - BASILAR-MEMBRANE

KW - MOUSE COCHLEA

U2 - 10.1016/bs.irn.2016.03.016

DO - 10.1016/bs.irn.2016.03.016

M3 - Chapter

SN - 978-0-12-803619-8

T3 - International Review of Neurobiology

SP - 369

EP - 399

BT - BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128

A2 - Contet, C

PB - Academic Press

ER -

ID: 37857640