Publication

BK Channels in the Vertebrate Inner Ear

Pyott, S. J. & Duncan, R. K., 2016, BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. Contet, C. (ed.). Academic Press, p. 369-399 31 p. (International Review of Neurobiology; vol. 128).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Copy link to clipboard

Documents

  • Chapter Ten - BK Channels in the Vertebrate Inner Ear

    Final publisher's version, 738 KB, PDF document

    Request copy

DOI

The perception of complex acoustic stimuli begins with the deconstruction of sound into its frequency components. This spectral processing occurs first and foremost in the inner ear. In vertebrates, two very different strategies of frequency analysis have evolved. In nonmammalian vertebrates, the sensory hair cells of the inner ear are intrinsically electrically tuned to a narrow band of acoustic frequencies. This electrical tuning relies on the interplay between BK channels and voltage-gated calcium channels. Systematic variations in BK channel density and kinetics establish a gradient in electrical resonance that enables the coding of a broad range of acoustic frequencies. In contrast, mammalian hair cells are extrinsically tuned by mechanical properties of the cochlear duct. Even so, mammalian hair cells also express BK channels. These BK channels play critical roles in various aspects of mammalian auditory signaling, from developmental maturation to protection against acoustic trauma. This review summarizes the anatomical localization, biophysical properties, and functional contributions of BK channels in vertebrate inner ears. Areas of future research, based on an updated understanding of the biology of both BK channels and the inner ear, are also highlighted. Investigation of BK channels in the inner ear continues to provide fertile research grounds for examining both BK channel biophysics and the molecular mechanisms underlying signal processing in the auditory periphery.

Original languageEnglish
Title of host publicationBIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128
EditorsC Contet
PublisherAcademic Press
Pages369-399
Number of pages31
ISBN (Print)978-0-12-803619-8
Publication statusPublished - 2016

Publication series

NameInternational Review of Neurobiology
PublisherELSEVIER ACADEMIC PRESS INC
Volume128
ISSN (Print)0074-7742

    Keywords

  • OUTER HAIR-CELLS, ACTIVATED POTASSIUM CHANNELS, CA2+-ACTIVATED K+ CHANNELS, GUINEA-PIG COCHLEA, MEDIATE CHOLINERGIC INHIBITION, REGULATORY BETA-1 SUBUNIT, LARGE-CONDUCTANCE, SPLICE VARIANTS, BASILAR-MEMBRANE, MOUSE COCHLEA

ID: 37857640