BK Channels in the Vertebrate Inner EarPyott, S. J. & Duncan, R. K., 2016, BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128. Contet, C. (ed.). Academic Press, p. 369-399 31 p. (International Review of Neurobiology; vol. 128).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
The perception of complex acoustic stimuli begins with the deconstruction of sound into its frequency components. This spectral processing occurs first and foremost in the inner ear. In vertebrates, two very different strategies of frequency analysis have evolved. In nonmammalian vertebrates, the sensory hair cells of the inner ear are intrinsically electrically tuned to a narrow band of acoustic frequencies. This electrical tuning relies on the interplay between BK channels and voltage-gated calcium channels. Systematic variations in BK channel density and kinetics establish a gradient in electrical resonance that enables the coding of a broad range of acoustic frequencies. In contrast, mammalian hair cells are extrinsically tuned by mechanical properties of the cochlear duct. Even so, mammalian hair cells also express BK channels. These BK channels play critical roles in various aspects of mammalian auditory signaling, from developmental maturation to protection against acoustic trauma. This review summarizes the anatomical localization, biophysical properties, and functional contributions of BK channels in vertebrate inner ears. Areas of future research, based on an updated understanding of the biology of both BK channels and the inner ear, are also highlighted. Investigation of BK channels in the inner ear continues to provide fertile research grounds for examining both BK channel biophysics and the molecular mechanisms underlying signal processing in the auditory periphery.
|Title of host publication||BIG ON BK: CURRENT INSIGHTS INTO THE FUNCTION OF LARGE CONDUCTANCE VOLTAGE- AND CA2+- ACTIVATED K+ CHANNELS AT THE MOLECULAR, CELLULAR, AND SYSTEMIC LEVELS, VOL 128|
|Number of pages||31|
|Publication status||Published - 2016|
|Name||International Review of Neurobiology|
|Publisher||ELSEVIER ACADEMIC PRESS INC|
- OUTER HAIR-CELLS, ACTIVATED POTASSIUM CHANNELS, CA2+-ACTIVATED K+ CHANNELS, GUINEA-PIG COCHLEA, MEDIATE CHOLINERGIC INHIBITION, REGULATORY BETA-1 SUBUNIT, LARGE-CONDUCTANCE, SPLICE VARIANTS, BASILAR-MEMBRANE, MOUSE COCHLEA