Bisecting Microfluidic Channels with Metallic Nanowires Fabricated by Nanoskiving

Kalkman, G. A., Zhang, Y., Monachino, E., Mathwig, K., Kamminga, M. E., Pourhossein Aghbolagh, P., Oomen, P. E., Stratmann, S. A., Zhao, Z., van Oijen, A. M., Verpoorte, E. & Chiechi, R. C., 5-Feb-2016, In : Acs Nano. 10, 2, p. 2852–2859 8 p.

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This paper describes the fabrication of millimeter-long gold nanowires that bisect the center of microfluidic channels. We fabricated the nanowires by nanoskiving and then suspended them over a trench in a glass structure. The channel was sealed by bonding it to a complementary poly(dimethylsiloxane) structure. The resulting structures place the nanowires in the region of highest flow, as opposed to the walls, where it approaches zero, and expose their entire surface area to fluid. We demonstrate active functionality, by constructing a hot-wire anemometer to measure flow through determining the change in resistance of the nanowire as a function of heat dissipation at low voltage (<5 V). Further, passive functionality is demonstrated by visualizing individual, fluorescently labeled DNA molecules attached to the wires. We measure rates of flow and show that, compared to surface-bound DNA strands, elongation saturates at lower rates of flow and background fluorescence from nonspecific binding is reduced.

Original languageEnglish
Pages (from-to)2852–2859
Number of pages8
JournalAcs Nano
Issue number2
Publication statusPublished - 5-Feb-2016


  • nanoskiving 3D nanofabrication, nanowires, microfluidics, single-molecule fluorescence imaging, COLI REP HELICASE, SINGLE-MOLECULE, DNA-MOLECULES, NANOSTRUCTURES, REPLICATION, ARRAYS, ELASTICITY, CURTAINS, TOOLS

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