Publication

Biosynthesis of archaeal membrane ether lipids

Jain, S., Caforio, A. & Driessen, A. J. M., 26-Nov-2014, In : Frontiers in Microbiology. 5, 16 p., 641.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Jain, S., Caforio, A., & Driessen, A. J. M. (2014). Biosynthesis of archaeal membrane ether lipids. Frontiers in Microbiology, 5, [641]. https://doi.org/10.3389/fmicb.2014.00641

Author

Jain, Samta ; Caforio, Antonella ; Driessen, Arnold J. M. / Biosynthesis of archaeal membrane ether lipids. In: Frontiers in Microbiology. 2014 ; Vol. 5.

Harvard

Jain, S, Caforio, A & Driessen, AJM 2014, 'Biosynthesis of archaeal membrane ether lipids', Frontiers in Microbiology, vol. 5, 641. https://doi.org/10.3389/fmicb.2014.00641

Standard

Biosynthesis of archaeal membrane ether lipids. / Jain, Samta; Caforio, Antonella; Driessen, Arnold J. M.

In: Frontiers in Microbiology, Vol. 5, 641, 26.11.2014.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Jain S, Caforio A, Driessen AJM. Biosynthesis of archaeal membrane ether lipids. Frontiers in Microbiology. 2014 Nov 26;5. 641. https://doi.org/10.3389/fmicb.2014.00641


BibTeX

@article{c858d18375c147c0aeb34b269333326e,
title = "Biosynthesis of archaeal membrane ether lipids",
abstract = "A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya. In archaea, isoprenoid hydrocarbon side chains are linked via an ether bond to the sn-glycerol-l-phosphate backbone. In bacteria and eukarya on the other hand, fatty acid side chains are linked via an ester bond to the sn-glycerol-3-phosphate backbone. The polar head groups are globally shared in the three domains of life. The unique membrane lipids of archaea have been implicated not only in the survival and adaptation of the organisms to extreme environments but also to form the basis of the membrane composition of the last universal common ancestor (LUCA). In nature, a diverse range of archaeal lipids is found, the most common are the diether (or archaeol) and the tetraether (or caldarchaeol) lipids that form a monolayer. Variations in chain length, cyclization and other modifications lead to diversification of these lipids. The biosynthesis of these lipids is not yet well understood however progress in the last decade has led to a comprehensive understanding of the biosynthesis of archaeol. This review describes the current knowledge of the biosynthetic pathway of archaeal ether lipids; insights on the stability and robustness of archaeal lipid membranes; and evolutionary aspects of the lipid divide and the LUCA. It examines recent advances made in the field of pathway reconstruction in bacteria.",
keywords = "archaea, ether lipids, isoprenoids, biosynthesis, lipid divide, GERANYLGERANYL-DIPHOSPHATE SYNTHASE, ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS, GLYCEROL TETRAETHER LIPIDS, CHAIN-LENGTH DETERMINATION, PHOSPHATE SYNTHASE, POLAR LIPIDS, SN-GLYCEROL-1-PHOSPHATE DEHYDROGENASE, METHANOBACTERIUM-THERMOAUTOTROPHICUM, THERMOACIDOPHILIC ARCHAEON, HYPERTHERMOPHILIC ARCHAEON",
author = "Samta Jain and Antonella Caforio and Driessen, {Arnold J. M.}",
year = "2014",
month = nov,
day = "26",
doi = "10.3389/fmicb.2014.00641",
language = "English",
volume = "5",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Biosynthesis of archaeal membrane ether lipids

AU - Jain, Samta

AU - Caforio, Antonella

AU - Driessen, Arnold J. M.

PY - 2014/11/26

Y1 - 2014/11/26

N2 - A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya. In archaea, isoprenoid hydrocarbon side chains are linked via an ether bond to the sn-glycerol-l-phosphate backbone. In bacteria and eukarya on the other hand, fatty acid side chains are linked via an ester bond to the sn-glycerol-3-phosphate backbone. The polar head groups are globally shared in the three domains of life. The unique membrane lipids of archaea have been implicated not only in the survival and adaptation of the organisms to extreme environments but also to form the basis of the membrane composition of the last universal common ancestor (LUCA). In nature, a diverse range of archaeal lipids is found, the most common are the diether (or archaeol) and the tetraether (or caldarchaeol) lipids that form a monolayer. Variations in chain length, cyclization and other modifications lead to diversification of these lipids. The biosynthesis of these lipids is not yet well understood however progress in the last decade has led to a comprehensive understanding of the biosynthesis of archaeol. This review describes the current knowledge of the biosynthetic pathway of archaeal ether lipids; insights on the stability and robustness of archaeal lipid membranes; and evolutionary aspects of the lipid divide and the LUCA. It examines recent advances made in the field of pathway reconstruction in bacteria.

AB - A vital function of the cell membrane in all living organism is to maintain the membrane permeability barrier and fluidity. The composition of the phospholipid bilayer is distinct in archaea when compared to bacteria and eukarya. In archaea, isoprenoid hydrocarbon side chains are linked via an ether bond to the sn-glycerol-l-phosphate backbone. In bacteria and eukarya on the other hand, fatty acid side chains are linked via an ester bond to the sn-glycerol-3-phosphate backbone. The polar head groups are globally shared in the three domains of life. The unique membrane lipids of archaea have been implicated not only in the survival and adaptation of the organisms to extreme environments but also to form the basis of the membrane composition of the last universal common ancestor (LUCA). In nature, a diverse range of archaeal lipids is found, the most common are the diether (or archaeol) and the tetraether (or caldarchaeol) lipids that form a monolayer. Variations in chain length, cyclization and other modifications lead to diversification of these lipids. The biosynthesis of these lipids is not yet well understood however progress in the last decade has led to a comprehensive understanding of the biosynthesis of archaeol. This review describes the current knowledge of the biosynthetic pathway of archaeal ether lipids; insights on the stability and robustness of archaeal lipid membranes; and evolutionary aspects of the lipid divide and the LUCA. It examines recent advances made in the field of pathway reconstruction in bacteria.

KW - archaea

KW - ether lipids

KW - isoprenoids

KW - biosynthesis

KW - lipid divide

KW - GERANYLGERANYL-DIPHOSPHATE SYNTHASE

KW - ARCHAEBACTERIUM SULFOLOBUS-ACIDOCALDARIUS

KW - GLYCEROL TETRAETHER LIPIDS

KW - CHAIN-LENGTH DETERMINATION

KW - PHOSPHATE SYNTHASE

KW - POLAR LIPIDS

KW - SN-GLYCEROL-1-PHOSPHATE DEHYDROGENASE

KW - METHANOBACTERIUM-THERMOAUTOTROPHICUM

KW - THERMOACIDOPHILIC ARCHAEON

KW - HYPERTHERMOPHILIC ARCHAEON

U2 - 10.3389/fmicb.2014.00641

DO - 10.3389/fmicb.2014.00641

M3 - Review article

VL - 5

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 641

ER -

ID: 16193367