Publication

Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A

Andra, S. S., Charisiadis, P., Arora, M., van Vliet-Ostaptchouk, J. V. & Makris, K. C., Dec-2015, In : Environment international. 85, p. 352-379 28 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Andra, S. S., Charisiadis, P., Arora, M., van Vliet-Ostaptchouk, J. V., & Makris, K. C. (2015). Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international, 85, 352-379. https://doi.org/10.1016/j.envint.2015.09.011

Author

Andra, Syam S. ; Charisiadis, Pantelis ; Arora, Manish ; van Vliet-Ostaptchouk, Jana V. ; Makris, Konstantinos C. / Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. In: Environment international. 2015 ; Vol. 85. pp. 352-379.

Harvard

Andra, SS, Charisiadis, P, Arora, M, van Vliet-Ostaptchouk, JV & Makris, KC 2015, 'Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A', Environment international, vol. 85, pp. 352-379. https://doi.org/10.1016/j.envint.2015.09.011

Standard

Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. / Andra, Syam S.; Charisiadis, Pantelis; Arora, Manish; van Vliet-Ostaptchouk, Jana V.; Makris, Konstantinos C.

In: Environment international, Vol. 85, 12.2015, p. 352-379.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Andra SS, Charisiadis P, Arora M, van Vliet-Ostaptchouk JV, Makris KC. Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international. 2015 Dec;85:352-379. https://doi.org/10.1016/j.envint.2015.09.011


BibTeX

@article{d9e750f1206e4324a1bca6fc05af1910,
title = "Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A",
abstract = "The high reactivity of bisphenol A (BPA) with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives (Cl(x)BPA) in various environmental media that show increased estrogen-activity when compared with that of BPA. The documented health risks associated with BPA exposures have led to the gradual market entry of BPA structural analogs, such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), etc. A suite of exposure sources to Cl(x)BPA and BPA analogs in the domestic environment is anticipated to drive the nature and range of halogenated BPA derivatives that can form when residual BPA comes in contact with disinfectant in tap water and/or consumer products. The primary objective of this review was to survey all available studies reporting biomonitoring protocols of Cl(x)BPA and structural BPA analogs (BPS, BPF, BPB, etc.) in human matrices. Focus was paid on describing the analytical methodologies practiced for the analysis of Cl(x)BPA and BPA analogs using hyphenated chromatography and mass spectrometry techniques, because current methodologies for human matrices are complex. During the last decade, an increasing number of ecotoxicological, cell-culture and animal-based and human studies dealing with Cl(x)BPA exposure sources and routes of exposure, metabolism and toxicity have been published. Up to date findings indicated the association of Cl(x)BPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly-in in-vitro and in-vivo studies. We critically discuss the limitations, research needs and future opportunities linked with the inclusion of Cl(x)BPA and BPA analogs into exposure assessment protocols of relevant epidemiological studies. (C) 2015 Elsevier Ltd. All rights reserved.",
author = "Andra, {Syam S.} and Pantelis Charisiadis and Manish Arora and {van Vliet-Ostaptchouk}, {Jana V.} and Makris, {Konstantinos C.}",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = dec,
doi = "10.1016/j.envint.2015.09.011",
language = "English",
volume = "85",
pages = "352--379",
journal = "Environment international",
issn = "0160-4120",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A

AU - Andra, Syam S.

AU - Charisiadis, Pantelis

AU - Arora, Manish

AU - van Vliet-Ostaptchouk, Jana V.

AU - Makris, Konstantinos C.

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/12

Y1 - 2015/12

N2 - The high reactivity of bisphenol A (BPA) with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives (Cl(x)BPA) in various environmental media that show increased estrogen-activity when compared with that of BPA. The documented health risks associated with BPA exposures have led to the gradual market entry of BPA structural analogs, such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), etc. A suite of exposure sources to Cl(x)BPA and BPA analogs in the domestic environment is anticipated to drive the nature and range of halogenated BPA derivatives that can form when residual BPA comes in contact with disinfectant in tap water and/or consumer products. The primary objective of this review was to survey all available studies reporting biomonitoring protocols of Cl(x)BPA and structural BPA analogs (BPS, BPF, BPB, etc.) in human matrices. Focus was paid on describing the analytical methodologies practiced for the analysis of Cl(x)BPA and BPA analogs using hyphenated chromatography and mass spectrometry techniques, because current methodologies for human matrices are complex. During the last decade, an increasing number of ecotoxicological, cell-culture and animal-based and human studies dealing with Cl(x)BPA exposure sources and routes of exposure, metabolism and toxicity have been published. Up to date findings indicated the association of Cl(x)BPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly-in in-vitro and in-vivo studies. We critically discuss the limitations, research needs and future opportunities linked with the inclusion of Cl(x)BPA and BPA analogs into exposure assessment protocols of relevant epidemiological studies. (C) 2015 Elsevier Ltd. All rights reserved.

AB - The high reactivity of bisphenol A (BPA) with disinfectant chlorine is evident in the instantaneous formation of chlorinated BPA derivatives (Cl(x)BPA) in various environmental media that show increased estrogen-activity when compared with that of BPA. The documented health risks associated with BPA exposures have led to the gradual market entry of BPA structural analogs, such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), etc. A suite of exposure sources to Cl(x)BPA and BPA analogs in the domestic environment is anticipated to drive the nature and range of halogenated BPA derivatives that can form when residual BPA comes in contact with disinfectant in tap water and/or consumer products. The primary objective of this review was to survey all available studies reporting biomonitoring protocols of Cl(x)BPA and structural BPA analogs (BPS, BPF, BPB, etc.) in human matrices. Focus was paid on describing the analytical methodologies practiced for the analysis of Cl(x)BPA and BPA analogs using hyphenated chromatography and mass spectrometry techniques, because current methodologies for human matrices are complex. During the last decade, an increasing number of ecotoxicological, cell-culture and animal-based and human studies dealing with Cl(x)BPA exposure sources and routes of exposure, metabolism and toxicity have been published. Up to date findings indicated the association of Cl(x)BPA with metabolic conditions, such as obesity, lipid accumulation, and type 2 diabetes mellitus, particularly-in in-vitro and in-vivo studies. We critically discuss the limitations, research needs and future opportunities linked with the inclusion of Cl(x)BPA and BPA analogs into exposure assessment protocols of relevant epidemiological studies. (C) 2015 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.envint.2015.09.011

DO - 10.1016/j.envint.2015.09.011

M3 - Review article

C2 - 26521216

VL - 85

SP - 352

EP - 379

JO - Environment international

JF - Environment international

SN - 0160-4120

ER -

ID: 30955264