Biomarkers for cellular senescenceDemaria, M., 13-Sep-2018, Patent No. WO2018164580, Priority date 9-Mar-2017
Research output: Patent › Professional
The invention relates to biomarkers and uses thereof, in particular to a set of proteins or mRNAs that provides a significant indication as to whether a cell is senescent or not. Provided is the use of a biomarker panel comprising six or more polypeptides, or their encoding mRNA's, wherein the panel comprises at least the biomarkers TSPAN13, GDNF, C2CD5, SUSD6, BCL2L2, PLK3, or a variant or fragment thereof, as a biomarker set for cellular senescence. Also provided is a senescent cell detection kit for detecting senescent cells, and a drug conjugate for killing a senescent cell.
|Publication status||Published - 13-Sep-2018|