Publication

Biomarkers and personalized medicine in heart failure

Tromp, J., 2018, [Groningen]: Rijksuniversiteit Groningen. 209 p.

Research output: ThesisThesis fully internal (DIV)

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Documents

  • Title and contents

    Final publisher's version, 1.58 MB, PDF document

  • Chapter 1

    Final publisher's version, 2.33 MB, PDF document

  • Chapter 2

    Final publisher's version, 1.66 MB, PDF document

  • Chapter 3

    Final publisher's version, 2.78 MB, PDF document

  • Chapter 4

    Final publisher's version, 5.43 MB, PDF document

  • Chapter 5

    Final publisher's version, 2.9 MB, PDF document

  • Chapter 6

    Final publisher's version, 2.4 MB, PDF document

  • Chapter 7

    Final publisher's version, 1.88 MB, PDF document

  • Chapter 8

    Final publisher's version, 1.57 MB, PDF document

  • Appendices

    Final publisher's version, 729 KB, PDF document

  • Complete thesis

    Final publisher's version, 10.3 MB, PDF document

  • Propositions

    Final publisher's version, 137 KB, PDF document

Treating heart failure is one of the greatest unmet needs in cardiovascular medicine today. Overall survival is poor and 50% of patients die within 5 years of their initial diagnosis. Heart failure is a heterogeneous syndrome and a one-size-fits-all approach is ineffective. Therefore, in my thesis I used biomarkers to 1. Show that patients with heart failure and a preserved ejection fraction are subject to more inflammation, which can be a key treatment target and 2. Identified clinical relevant subgroups with differences in response to treatment using machine learning based approaches.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date17-Sep-2018
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-034-1064-7
Electronic ISBNs978-94-034-1063-0
Publication statusPublished - 2018

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