Publication

Biomarker discovery by proteomics: challenges not only for the analytical chemist

Horvatovich, P., Govorukhina, N. & Bischoff, R., 2006, In : Analyst.. 131, 11, p. 1193-1196 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

This forum article outlines some of the major challenges in present day biomarker discovery research. Notably the dilemma of reaching sufficient concentration sensitivity versus the required analysis time per sample is highlighted using a model calculation. A number of possible developments and recent research findings are considered to show possible ways out of this dilemma. Finally, the challenge of processing large, megavariate datasets prior to statistical analysis is presented.

Original languageEnglish
Pages (from-to)1193-1196
Number of pages4
JournalAnalyst.
Volume131
Issue number11
Publication statusPublished - 2006

    Keywords

  • TANDEM MASS-SPECTROMETRY, HUMAN SERUM, DISEASE CLASSIFICATION, SEPARATIONS, EXPRESSION

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