Biomarker discovery by proteomics: challenges not only for the analytical chemistHorvatovich, P., Govorukhina, N. & Bischoff, R., 2006, In : Analyst.. 131, 11, p. 1193-1196 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
This forum article outlines some of the major challenges in present day biomarker discovery research. Notably the dilemma of reaching sufficient concentration sensitivity versus the required analysis time per sample is highlighted using a model calculation. A number of possible developments and recent research findings are considered to show possible ways out of this dilemma. Finally, the challenge of processing large, megavariate datasets prior to statistical analysis is presented.
|Number of pages||4|
|Publication status||Published - 2006|
- TANDEM MASS-SPECTROMETRY, HUMAN SERUM, DISEASE CLASSIFICATION, SEPARATIONS, EXPRESSION