Bile acid homeostasis in gastrointestinal and metabolic complications of cystic fibrosisvan de Peppel, I. P., Bodewes, F. A. J. A., Verkade, H. J. & Jonker, J. W., May-2019, In : Journal of Cystic Fibrosis. 18, 3, p. 313-320 8 p.
Research output: Contribution to journal › Review article › Academic › peer-review
With the improved treatment of the pulmonary complications of cystic fibrosis (CF), gastrointestinal problems have become more important in the morbidity in CF. A hallmark of the gastrointestinal phenotype of CF, apart from pancreatic insufficiency, is a disruption of bile acid homeostasis. Bile acid homeostasis is important for many gastrointestinal processes including fat absorption, inflammation, microbial composition, as well as regulation of whole body energy metabolism. This review describes the impairment of bile acid homeostasis in CF, its possible consequences for gastrointestinal and metabolic complications and its potential as a target for therapy. (C) 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
|Number of pages||8|
|Journal||Journal of Cystic Fibrosis|
|Publication status||Published - May-2019|
- Cystic fibrosis, Bile acids, Metabolism, Intestine, Liver, FARNESOID-X-RECEPTOR, TRANSMEMBRANE CONDUCTANCE REGULATOR, BETA-MURICHOLIC ACID, GROWTH-FACTOR 15, URSODEOXYCHOLIC ACID, GUT MICROBIOTA, LIVER-DISEASE, SUPPLEMENTATION IMPROVES, INTESTINAL-OBSTRUCTION, HEPATOBILIARY DISEASE