Publication

Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers

Vos, J. R., Oosterwijk, J. C., Aalfs, C. M., Rookus, M. A., Adank, M. A., van der Hout, A. H., van Asperen, C. J., Garcia, E. B. G., Mensenkamp, A. R., Jager, A., Ausems, M. G. E. M., Mourits, M. J., de Bock, G. H. & Hereditary Breast Ovarian Canc Res, Aug-2016, In : CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 25, 8, p. 1251-1258 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Vos, J. R., Oosterwijk, J. C., Aalfs, C. M., Rookus, M. A., Adank, M. A., van der Hout, A. H., van Asperen, C. J., Garcia, E. B. G., Mensenkamp, A. R., Jager, A., Ausems, M. G. E. M., Mourits, M. J., de Bock, G. H., & Hereditary Breast Ovarian Canc Res (2016). Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 25(8), 1251-1258. https://doi.org/10.1158/1055-9965.EPI-16-0182

Author

Vos, Janet R. ; Oosterwijk, Jan C. ; Aalfs, Cora M. ; Rookus, Matti A. ; Adank, Muriel A. ; van der Hout, Annemarie H. ; van Asperen, Christi J. ; Garcia, Encarna B. Gomez ; Mensenkamp, Arjen R. ; Jager, Agnes ; Ausems, Margreet G. E. M. ; Mourits, Marian J. ; de Bock, Geertruida H. ; Hereditary Breast Ovarian Canc Res. / Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers. In: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2016 ; Vol. 25, No. 8. pp. 1251-1258.

Harvard

Vos, JR, Oosterwijk, JC, Aalfs, CM, Rookus, MA, Adank, MA, van der Hout, AH, van Asperen, CJ, Garcia, EBG, Mensenkamp, AR, Jager, A, Ausems, MGEM, Mourits, MJ, de Bock, GH & Hereditary Breast Ovarian Canc Res 2016, 'Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers', CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, vol. 25, no. 8, pp. 1251-1258. https://doi.org/10.1158/1055-9965.EPI-16-0182

Standard

Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers. / Vos, Janet R.; Oosterwijk, Jan C.; Aalfs, Cora M.; Rookus, Matti A.; Adank, Muriel A.; van der Hout, Annemarie H.; van Asperen, Christi J.; Garcia, Encarna B. Gomez; Mensenkamp, Arjen R.; Jager, Agnes; Ausems, Margreet G. E. M.; Mourits, Marian J.; de Bock, Geertruida H.; Hereditary Breast Ovarian Canc Res.

In: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol. 25, No. 8, 08.2016, p. 1251-1258.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Vos JR, Oosterwijk JC, Aalfs CM, Rookus MA, Adank MA, van der Hout AH et al. Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2016 Aug;25(8):1251-1258. https://doi.org/10.1158/1055-9965.EPI-16-0182


BibTeX

@article{5a17996e15404d7bae16192350aa40b8,
title = "Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers",
abstract = "Background: Paternal transmission of a BRCA mutation has been reported to increase the risk of breast cancer in offspring more than when the mutation is maternally inherited. As this effect might be caused by referral bias, the aim of this study was to assess the parent-of-origin effect of the BRCA1/2 mutation on the breast cancer lifetime risk, when adjusted for referral bias.Methods: A Dutch national cohort including 1,314 proven BRCA1/2 mutation carriers and covering 54,752 person years. Data were collected by family cancer clinics, via questionnaires and from the national Dutch Cancer Registry. The parent-of-origin effect was assessed using Cox regression analyses, both unadjusted and adjusted for referral bias. Referral bias was operationalized by number of relatives with cancer and by personal cancer history.Results: The mutation was of paternal origin in 330 (42%, P <0.001) BRCA1 and 222 (42%, P <0.001) BRCA2 carriers. Paternal origin increased the risk of prevalent breast cancer for BRCA1 [HR, 1.54; 95% confidence interval (CI), 1.19-2.00] and BRCA2 carriers (HR, 1.40; 95% CI, 0.95-2.06). Adjusted for referral bias by several family history factors, these HRs ranged from 1.41 to 1.83 in BRCA1 carriers and 1.27 to 1.62 in BRCA2 carriers. Adjusted for referral bias by personal history, these HRs were 0.66 (95% CI, 0.25-1.71) and 1.14 (95% CI, 0.42-3.15), respectively.Conclusion: A parent-of-origin effect is present after correction for referral bias by family history, but correction for the personal cancer history made the effect disappear.Impact: There is no conclusive evidence regarding incorporating a BRCA1/2 parent-of-origin effect in breast cancer risk prediction models. (C) 2016 AACR.",
keywords = "FAMILY-HISTORY, OVARIAN-CANCER, WOMEN, AGE, COMMUNICATION, INFORMATION, PENETRANCE, ACCURACY, PREDICT, ONSET",
author = "Vos, {Janet R.} and Oosterwijk, {Jan C.} and Aalfs, {Cora M.} and Rookus, {Matti A.} and Adank, {Muriel A.} and {van der Hout}, {Annemarie H.} and {van Asperen}, {Christi J.} and Garcia, {Encarna B. Gomez} and Mensenkamp, {Arjen R.} and Agnes Jager and Ausems, {Margreet G. E. M.} and Mourits, {Marian J.} and {de Bock}, {Geertruida H.} and {Hereditary Breast Ovarian Canc Res}",
note = "Copyright {\textcopyright}2016, American Association for Cancer Research.",
year = "2016",
month = aug,
doi = "10.1158/1055-9965.EPI-16-0182",
language = "English",
volume = "25",
pages = "1251--1258",
journal = "CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION",
issn = "1055-9965",
publisher = "AMER ASSOC CANCER RESEARCH",
number = "8",

}

RIS

TY - JOUR

T1 - Bias explains most of the parent-of-origin effect on breast cancer risk in BRCA1/2 mutation carriers

AU - Vos, Janet R.

AU - Oosterwijk, Jan C.

AU - Aalfs, Cora M.

AU - Rookus, Matti A.

AU - Adank, Muriel A.

AU - van der Hout, Annemarie H.

AU - van Asperen, Christi J.

AU - Garcia, Encarna B. Gomez

AU - Mensenkamp, Arjen R.

AU - Jager, Agnes

AU - Ausems, Margreet G. E. M.

AU - Mourits, Marian J.

AU - de Bock, Geertruida H.

AU - Hereditary Breast Ovarian Canc Res

N1 - Copyright ©2016, American Association for Cancer Research.

PY - 2016/8

Y1 - 2016/8

N2 - Background: Paternal transmission of a BRCA mutation has been reported to increase the risk of breast cancer in offspring more than when the mutation is maternally inherited. As this effect might be caused by referral bias, the aim of this study was to assess the parent-of-origin effect of the BRCA1/2 mutation on the breast cancer lifetime risk, when adjusted for referral bias.Methods: A Dutch national cohort including 1,314 proven BRCA1/2 mutation carriers and covering 54,752 person years. Data were collected by family cancer clinics, via questionnaires and from the national Dutch Cancer Registry. The parent-of-origin effect was assessed using Cox regression analyses, both unadjusted and adjusted for referral bias. Referral bias was operationalized by number of relatives with cancer and by personal cancer history.Results: The mutation was of paternal origin in 330 (42%, P <0.001) BRCA1 and 222 (42%, P <0.001) BRCA2 carriers. Paternal origin increased the risk of prevalent breast cancer for BRCA1 [HR, 1.54; 95% confidence interval (CI), 1.19-2.00] and BRCA2 carriers (HR, 1.40; 95% CI, 0.95-2.06). Adjusted for referral bias by several family history factors, these HRs ranged from 1.41 to 1.83 in BRCA1 carriers and 1.27 to 1.62 in BRCA2 carriers. Adjusted for referral bias by personal history, these HRs were 0.66 (95% CI, 0.25-1.71) and 1.14 (95% CI, 0.42-3.15), respectively.Conclusion: A parent-of-origin effect is present after correction for referral bias by family history, but correction for the personal cancer history made the effect disappear.Impact: There is no conclusive evidence regarding incorporating a BRCA1/2 parent-of-origin effect in breast cancer risk prediction models. (C) 2016 AACR.

AB - Background: Paternal transmission of a BRCA mutation has been reported to increase the risk of breast cancer in offspring more than when the mutation is maternally inherited. As this effect might be caused by referral bias, the aim of this study was to assess the parent-of-origin effect of the BRCA1/2 mutation on the breast cancer lifetime risk, when adjusted for referral bias.Methods: A Dutch national cohort including 1,314 proven BRCA1/2 mutation carriers and covering 54,752 person years. Data were collected by family cancer clinics, via questionnaires and from the national Dutch Cancer Registry. The parent-of-origin effect was assessed using Cox regression analyses, both unadjusted and adjusted for referral bias. Referral bias was operationalized by number of relatives with cancer and by personal cancer history.Results: The mutation was of paternal origin in 330 (42%, P <0.001) BRCA1 and 222 (42%, P <0.001) BRCA2 carriers. Paternal origin increased the risk of prevalent breast cancer for BRCA1 [HR, 1.54; 95% confidence interval (CI), 1.19-2.00] and BRCA2 carriers (HR, 1.40; 95% CI, 0.95-2.06). Adjusted for referral bias by several family history factors, these HRs ranged from 1.41 to 1.83 in BRCA1 carriers and 1.27 to 1.62 in BRCA2 carriers. Adjusted for referral bias by personal history, these HRs were 0.66 (95% CI, 0.25-1.71) and 1.14 (95% CI, 0.42-3.15), respectively.Conclusion: A parent-of-origin effect is present after correction for referral bias by family history, but correction for the personal cancer history made the effect disappear.Impact: There is no conclusive evidence regarding incorporating a BRCA1/2 parent-of-origin effect in breast cancer risk prediction models. (C) 2016 AACR.

KW - FAMILY-HISTORY

KW - OVARIAN-CANCER

KW - WOMEN

KW - AGE

KW - COMMUNICATION

KW - INFORMATION

KW - PENETRANCE

KW - ACCURACY

KW - PREDICT

KW - ONSET

U2 - 10.1158/1055-9965.EPI-16-0182

DO - 10.1158/1055-9965.EPI-16-0182

M3 - Article

C2 - 27277847

VL - 25

SP - 1251

EP - 1258

JO - CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

JF - CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

SN - 1055-9965

IS - 8

ER -

ID: 33000157