Beyond sepsis: activated protein C and ischemia-reperfusion injury

Levi, M., Choi, G., Schoots, I., Schultz, M. & van der Poll, T., May-2004, In : Critical Care Medicine. 32, 5 Suppl, p. S309-S312

Research output: Contribution to journalArticleAcademicpeer-review

  • Marcel Levi
  • Goda Choi
  • Ivo Schoots
  • Marcus Schultz
  • Tom van der Poll

OBJECTIVE: To review potential clinical situations beyond sepsis in which activated protein C might be an effective treatment.

DATA SOURCE: Published articles between 1970 and 2003 on experimental and clinical studies of activation of both coagulation and inflammation in various disease states.

DATA SYNTHESIS AND CONCLUSION: The efficacy of activated protein C in sepsis might rely on the fact that it can modulate both coagulation and inflammation. Therefore, administration of activated protein C could be beneficial in disease states that are also characterized by the simultaneous activation of these systems. Ischemia-reperfusion injury of various organs may represent such a state. Indeed, the involvement of the protein C system has been demonstrated in various experimental studies of ischemia-reperfusion, including studies in renal ischemia-reperfusion syndromes, coronary atherosclerosis and acute coronary syndromes, and intestinal ischemia and reperfusion. In some of these models, activated protein C administration, or other interventions in the protein C system, was shown to be beneficial.

Original languageEnglish
Pages (from-to)S309-S312
JournalCritical Care Medicine
Issue number5 Suppl
Publication statusPublished - May-2004


  • Animals, Anti-Infective Agents, Humans, Protein C, Recombinant Proteins, Reperfusion Injury, Sepsis

ID: 29061301