Publication

Beyond intestinal soap-bile acids in metabolic control

Kuipers, F., Bloks, V. W. & Groen, A. K., Aug-2014, In : Nature reviews endocrinology. 10, 8, p. 488-498 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Kuipers, F., Bloks, V. W., & Groen, A. K. (2014). Beyond intestinal soap-bile acids in metabolic control. Nature reviews endocrinology, 10(8), 488-498. https://doi.org/10.1038/nrendo.2014.60

Author

Kuipers, Folkert ; Bloks, Vincent W. ; Groen, Albert K. / Beyond intestinal soap-bile acids in metabolic control. In: Nature reviews endocrinology. 2014 ; Vol. 10, No. 8. pp. 488-498.

Harvard

Kuipers, F, Bloks, VW & Groen, AK 2014, 'Beyond intestinal soap-bile acids in metabolic control', Nature reviews endocrinology, vol. 10, no. 8, pp. 488-498. https://doi.org/10.1038/nrendo.2014.60

Standard

Beyond intestinal soap-bile acids in metabolic control. / Kuipers, Folkert; Bloks, Vincent W.; Groen, Albert K.

In: Nature reviews endocrinology, Vol. 10, No. 8, 08.2014, p. 488-498.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap-bile acids in metabolic control. Nature reviews endocrinology. 2014 Aug;10(8):488-498. https://doi.org/10.1038/nrendo.2014.60


BibTeX

@article{21bd813cdcfb4c3ab01a72bd6f6d5dde,
title = "Beyond intestinal soap-bile acids in metabolic control",
abstract = "Over the past decade, it has become apparent that bile acids are involved in a host of activities beyond their classic functions in bile formation and fat absorption. The identification of the farnesoid X receptor (FXR) as a nuclear receptor directly activated by bile acids and the discovery that bile acids are also ligands for the membrane-bound, G-protein coupled bile acid receptor 1 (also known as TGR5) have opened new avenues of research. Both FXR and TGR5 regulate various elements of glucose, lipid and energy metabolism. Consequently, a picture has emerged of bile acids acting as modulators of (postprandial) metabolism. Therefore, strategies that interfere with either bile acid metabolism or signalling cascades mediated by bile acids may represent novel therapeutic approaches for metabolic diseases. Synthetic modulators of FXR have been designed and tested, primarily in animal models. Furthermore, the use of bile acid sequestrants to reduce plasma cholesterol levels has unexpected benefits. For example, treatment of patients with type 2 diabetes mellitus (T2DM) with sequestrants causes substantial reductions in plasma levels of glucose and HbA(1c). This Review aims to provide an overview of the molecular mechanisms by which bile acids modulate glucose and energy metabolism, particularly focusing on the glucose-lowering actions of bile acid sequestrants in insulin resistant states and T2DM.",
keywords = "FARNESOID-X-RECEPTOR, Y GASTRIC BYPASS, FIBROBLAST GROWTH-FACTORS, TYPE-2 DIABETES-MELLITUS, ORPHAN NUCLEAR RECEPTOR, GLUCAGON-LIKE PEPTIDE-1, DIET-INDUCED OBESITY, GLYCEMIC CONTROL, ENERGY-EXPENDITURE, COLESEVELAM HYDROCHLORIDE",
author = "Folkert Kuipers and Bloks, {Vincent W.} and Groen, {Albert K.}",
year = "2014",
month = aug,
doi = "10.1038/nrendo.2014.60",
language = "English",
volume = "10",
pages = "488--498",
journal = "Nature reviews endocrinology",
issn = "1759-5029",
publisher = "Nature Publishing Group",
number = "8",

}

RIS

TY - JOUR

T1 - Beyond intestinal soap-bile acids in metabolic control

AU - Kuipers, Folkert

AU - Bloks, Vincent W.

AU - Groen, Albert K.

PY - 2014/8

Y1 - 2014/8

N2 - Over the past decade, it has become apparent that bile acids are involved in a host of activities beyond their classic functions in bile formation and fat absorption. The identification of the farnesoid X receptor (FXR) as a nuclear receptor directly activated by bile acids and the discovery that bile acids are also ligands for the membrane-bound, G-protein coupled bile acid receptor 1 (also known as TGR5) have opened new avenues of research. Both FXR and TGR5 regulate various elements of glucose, lipid and energy metabolism. Consequently, a picture has emerged of bile acids acting as modulators of (postprandial) metabolism. Therefore, strategies that interfere with either bile acid metabolism or signalling cascades mediated by bile acids may represent novel therapeutic approaches for metabolic diseases. Synthetic modulators of FXR have been designed and tested, primarily in animal models. Furthermore, the use of bile acid sequestrants to reduce plasma cholesterol levels has unexpected benefits. For example, treatment of patients with type 2 diabetes mellitus (T2DM) with sequestrants causes substantial reductions in plasma levels of glucose and HbA(1c). This Review aims to provide an overview of the molecular mechanisms by which bile acids modulate glucose and energy metabolism, particularly focusing on the glucose-lowering actions of bile acid sequestrants in insulin resistant states and T2DM.

AB - Over the past decade, it has become apparent that bile acids are involved in a host of activities beyond their classic functions in bile formation and fat absorption. The identification of the farnesoid X receptor (FXR) as a nuclear receptor directly activated by bile acids and the discovery that bile acids are also ligands for the membrane-bound, G-protein coupled bile acid receptor 1 (also known as TGR5) have opened new avenues of research. Both FXR and TGR5 regulate various elements of glucose, lipid and energy metabolism. Consequently, a picture has emerged of bile acids acting as modulators of (postprandial) metabolism. Therefore, strategies that interfere with either bile acid metabolism or signalling cascades mediated by bile acids may represent novel therapeutic approaches for metabolic diseases. Synthetic modulators of FXR have been designed and tested, primarily in animal models. Furthermore, the use of bile acid sequestrants to reduce plasma cholesterol levels has unexpected benefits. For example, treatment of patients with type 2 diabetes mellitus (T2DM) with sequestrants causes substantial reductions in plasma levels of glucose and HbA(1c). This Review aims to provide an overview of the molecular mechanisms by which bile acids modulate glucose and energy metabolism, particularly focusing on the glucose-lowering actions of bile acid sequestrants in insulin resistant states and T2DM.

KW - FARNESOID-X-RECEPTOR

KW - Y GASTRIC BYPASS

KW - FIBROBLAST GROWTH-FACTORS

KW - TYPE-2 DIABETES-MELLITUS

KW - ORPHAN NUCLEAR RECEPTOR

KW - GLUCAGON-LIKE PEPTIDE-1

KW - DIET-INDUCED OBESITY

KW - GLYCEMIC CONTROL

KW - ENERGY-EXPENDITURE

KW - COLESEVELAM HYDROCHLORIDE

U2 - 10.1038/nrendo.2014.60

DO - 10.1038/nrendo.2014.60

M3 - Review article

C2 - 24821328

VL - 10

SP - 488

EP - 498

JO - Nature reviews endocrinology

JF - Nature reviews endocrinology

SN - 1759-5029

IS - 8

ER -

ID: 13705545