Publication
Beyond genome wide association studies in celiac disease by exploring the non-coding genome
de Almeida, R., 2015, [S.l.]: [S.n.]. 223 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Title and contents
Final publisher's version, 411 KB, PDF document
- Chapter 1
Final publisher's version, 1.13 MB, PDF document
- Chapter 2
Final publisher's version, 4.54 MB, PDF document
- Chapter 3
Final publisher's version, 1.07 MB, PDF document
- Chapter 4
Final publisher's version, 2.23 MB, PDF document
- Chapter 5
Final publisher's version, 3.41 MB, PDF document
- Chapter 6
Final publisher's version, 1.03 MB, PDF document
- Chapter 7
Final publisher's version, 1.67 MB, PDF document
- Chapter 8
Final publisher's version, 2.47 MB, PDF document
- Appendices
Final publisher's version, 2.52 MB, PDF document
- Complete dissertation
Final publisher's version, 8.9 MB, PDF document
- Propositions
Final publisher's version, 129 KB, PDF document
Recent studies have identified 40 regions in the human genome that predispose to the development of celiac disease. In this thesis, I applied statistical genetics and pathway analysis methods to gain a better understanding of how the predisposing genetic factors contribute to celiac disease. I prioritize functional variants, genes and pathways affected in celiac disease, including a long non-coding RNA that is regulated by a celiac-associated genetic variant.
An exciting development is that circulating micro-RNA molecules have been identified as a new class of biomarkers for immune-mediated diseases. I found microRNAs candidates that can be used as novel biomarkers for celiac disease development and to monitor a patient’s adherence to the gluten-free diet. These biomarkers can be developed into useful clinical tests.
Translated title of the contribution | De volgende stap na genoom-wijde associatie studies: de rol van het niet-coderende genoom |
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Original language | English |
Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 25-Mar-2015 |
Place of Publication | [S.l.] |
Publisher | |
Print ISBNs | 978-90-367-7718-6 |
Electronic ISBNs | 978-90-367-7760-5 |
Publication status | Published - 2015 |
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