Behandeling van het acute herseninfarct met intraveneuze trombolyse: meer tijd, maar geen minuut te verliezen

Uyttenboogaart, M., Luijckx, G. J., Kappelle, L. J., van Oostenbrugge, R. J., Dippel, D. W. J. & Stam, J., 6-Dec-2008, In : Nederlands Tijdschrift voor Geneeskunde. 152, 49, p. 2653-2655 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

In the European Cooperative Acute Stroke Study 3 (ECASS3), the efficacy of intravenous thrombolysis between 3 and 4.5 hours following onset of ischaemic stroke was investigated. Compared to the placebo group, patients treated with intravenous alteplase had a better functional outcome after 3 months (odds ratio 1.34, 95% confidence interval 1.02-1.76). The risk of symptomatic intracerebral haemorrhage was higher in the alteplase group (2.4% versus 0.3%). The time window for intravenous alteplase can be safely extended to 4.5 hours, but efforts should be made to start treatment as soon as possible, since the effectiveness ofalteplase decreases over time.

Translated title of the contributionTreatment of acute ischemic stroke with intravenous thrombolysis: extension of the time window should not delay initiation of treatment
Original languageDutch
Pages (from-to)2653-2655
Number of pages3
JournalNederlands Tijdschrift voor Geneeskunde
Issue number49
Publication statusPublished - 6-Dec-2008


  • Fibrinolytic Agents, Humans, Stroke, Thrombolytic Therapy, Time Factors, Treatment Outcome

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