Publication

BEACON: A Summary Framework to Overcome Potential Reimbursement Hurdles

Dunlop, W. C. N., Mullins, C. D., Pirk, O., Goeree, R., Postma, M. J., Enstone, A. & Heron, L., Oct-2016, In : Pharmacoeconomics. 34, 10, p. 1051-1065 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • William C. N. Dunlop
  • C. Daniel Mullins
  • Olaf Pirk
  • Ron Goeree
  • Maarten J. Postma
  • Ashley Enstone
  • Louise Heron

Objective To provide a framework for addressing payers' criteria during the development of pharmaceuticals.

Methods A conceptual framework was presented to an international health economic expert panel for discussion. A structured literature search (from 2010 to May 2015), using the following databases in Ovid: Medline((R)) and Medline((R)) In-Process (PubMed), Embase (Ovid), EconLit (EBSCOhost) and the National Health Service Economic Evaluation Database (NHS EED), and a 'grey literature' search, were conducted to identify existing criteria from the payer perspective. The criteria assessed by existing frameworks and guidelines were collated; the most commonly reported criteria were considered for inclusion in the framework. A mnemonic was conceived as a memory aide to summarise these criteria.

Results Overall, 41 publications were identified as potentially relevant to the objective. Following further screening, 26 were excluded upon full-text review on the basis of no framework presented (n = 13), redundancy (n = 11) or abstract only (n = 2). Frameworks that captured criteria developed for or utilised by the pharmaceutical industry (n = 5) and reimbursement guidance (n = 10) were reviewed. The most commonly identified criteria-unmet need/patient burden, safety, efficacy, quality-of-life outcomes, environment, evidence quality, budget impact and comparator-were incorporated into the summary framework. For ease of communication, the following mnemonic was developed: BEACON (Burden/target population, Environment, Affordability/value, Comparator, Outcomes, Number of studies/quality of evidence).

Conclusions The BEACON framework aims to capture the 'essence' of payer requirements by addressing the most commonly described criteria requested by payers regarding the introduction of a new pharmaceutical.

Original languageEnglish
Pages (from-to)1051-1065
Number of pages15
JournalPharmacoeconomics
Volume34
Issue number10
Publication statusPublished - Oct-2016

    Keywords

  • MULTICRITERIA DECISION-ANALYSIS, HEALTH TECHNOLOGY-ASSESSMENT, MEDICINES, WORLD

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