Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndrome

Nakshbandi, U., Haacke, E. A., Bootsma, H., Vissink, A., Spijkervet, F. K. L., van der Vegt, B. & Kroese, F. G. M., 28-Jan-2020, In : Oral diseases. 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).

Original languageEnglish
Number of pages4
JournalOral diseases
Early online date7-Jan-2020
Publication statusPublished - 28-Jan-2020


  • B-cell hyperactivity, germinal centre, lymphoid organisation, primary Sjogren's syndrome, LYMPHOID ORGANIZATION, STANDARDIZATION, HISTOPATHOLOGY

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