Bcl6 for identification of germinal centres in salivary gland biopsies in primary Sjogren's syndromeNakshbandi, U., Haacke, E. A., Bootsma, H., Vissink, A., Spijkervet, F. K. L., van der Vegt, B. & Kroese, F. G. M., 28-Jan-2020, In : Oral diseases. 4 p.
Research output: Contribution to journal › Article › Academic › peer-review
Histopathological assessment of salivary gland biopsies is an important element of the diagnostic work-up of Sjögren's syndrome (SS) (Fox, 2017; Kroese et al., 2018). Microscopic evaluation of salivary glands of primary SS (pSS) patients reveals characteristic periductal lymphocytic infiltrates (foci), which mainly consist of T- and B-lymphocytes, as well as a variety of non-lymphoid cells, including dendritic cells and macrophages. Over time, these infiltrates may become organised to ectopic lymphoid tissue with T/B cell compartmentalisation, presence of CD21+ follicular dendritic cell (FDC) networks and high endothelial venules (Fisher et al., 2017; Kroese et al., 2014; Kroese et al., 2018; Salomonsson et al., 2003).
|Number of pages||4|
|Early online date||7-Jan-2020|
|Publication status||Published - 28-Jan-2020|
- B-cell hyperactivity, germinal centre, lymphoid organisation, primary Sjogren's syndrome, LYMPHOID ORGANIZATION, STANDARDIZATION, HISTOPATHOLOGY