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Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

Kakkar, V., Meister-Broekema, M., Minoia, M., Carra, S. & Kampinga, H. H., Apr-2014, In : Disease models & mechanisms. 7, 4, p. 421-434 14 p.

Research output: Contribution to journalReview articleAcademicpeer-review

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  • Vaishali Kakkar
  • Melanie Meister-Broekema
  • Melania Minoia
  • Serena Carra
  • Harm H. Kampinga

There are numerous human diseases that are associated with protein misfolding and the formation of toxic protein aggregates. Activating the heat shock response (HSR) - and thus generally restoring the disturbed protein homeostasis associated with such diseases - has often been suggested as a therapeutic strategy. However, most data on activating the HSR or its downstream targets in mouse models of diseases associated with aggregate formation have been rather disappointing. The human chaperonome consists of many more heat shock proteins (HSPs) that are not regulated by the HSR, however, and researchers are now focusing on these as potential therapeutic targets. In this Review, we summarize the existing literature on a set of aggregation diseases and propose that each of them can be characterized or `barcoded' by a different set of HSPs that can rescue specific types of aggregation. Some of these 'non-canonical' HSPs have demonstrated effectiveness in vivo, in mouse models of protein-aggregation disease. Interestingly, several of these HSPs also cause diseases when mutated - so-called chaperonopathies - which are also discussed in this Review.

Original languageEnglish
Pages (from-to)421-434
Number of pages14
JournalDisease models & mechanisms
Volume7
Issue number4
Publication statusPublished - Apr-2014

    Keywords

  • Chaperonopathies, Heat shock protein, Protein-aggregation diseases, AMYOTROPHIC-LATERAL-SCLEROSIS, ALPHA-B-CRYSTALLIN, UBIQUITIN-PROTEASOME SYSTEM, RECESSIVE SPASTIC ATAXIA, TRANSGENIC MOUSE MODEL, BARDET-BIEDL-SYNDROME, POLYGLUTAMINE-INDUCED NEURODEGENERATION, SYNUCLEIN-INDUCED TOXICITY, AGGREGATION IN-VITRO, MOLECULAR CHAPERONES

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