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Autophagy regulation through Atg9 traffic

Tooze, S. A. & Reggiori, F., 23-Jul-2012, In : The Journal of Cell Biology. 198, 2, p. 151-153 3 p.

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DOI

Rapid membrane expansion is the key to autophagosome formation during nutrient starvation. In this issue, Yamamoto et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201202061) now provide a mechanism for vesicle-mediated initiation of autophagosome biogenesis. They show that Atg9 vesicles, produced de novo during starvation, are ∼30-60 nm in size and contain ∼30 molecules of Atg9. These vesicles assemble to form an autophagosome, and subsequently, the Atg9 embedded in the outer membrane is recycled to avoid degradation.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalThe Journal of Cell Biology
Volume198
Issue number2
Publication statusPublished - 23-Jul-2012
Externally publishedYes

    Keywords

  • Intracellular Membranes, Membrane Proteins, Phagosomes, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins

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