Publication

Autophagy in unicellular eukaryotes

Kiel, J. A. K. W., 12-Mar-2010, In : Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 365, 1541, p. 819 - 830 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Kiel, J. A. K. W. (2010). Autophagy in unicellular eukaryotes. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 365(1541), 819 - 830. https://doi.org/10.1098/rstb.2009.0237

Author

Kiel, J.A.K.W. / Autophagy in unicellular eukaryotes. In: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 2010 ; Vol. 365, No. 1541. pp. 819 - 830.

Harvard

Kiel, JAKW 2010, 'Autophagy in unicellular eukaryotes', Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, vol. 365, no. 1541, pp. 819 - 830. https://doi.org/10.1098/rstb.2009.0237

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Autophagy in unicellular eukaryotes. / Kiel, J.A.K.W.

In: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 365, No. 1541, 12.03.2010, p. 819 - 830.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Kiel JAKW. Autophagy in unicellular eukaryotes. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 2010 Mar 12;365(1541):819 - 830. https://doi.org/10.1098/rstb.2009.0237


BibTeX

@article{d989fdd85912431d8617bf799b8ebd38,
title = "Autophagy in unicellular eukaryotes",
abstract = "Cells need a constant supply of precursors to enable the production of macromolecules to sustain growth and survival. Unlike metazoans, unicellular eukaryotes depend exclusively on the extracellular medium for this supply. When environmental nutrients become depleted, existing cytoplasmic components will be catabolized by (macro) autophagy in order to re-use building blocks and to support ATP production. In many cases, autophagy takes care of cellular housekeeping to sustain cellular viability. Autophagy encompasses a multitude of related and often highly specific processes that are implicated in both biogenetic and catabolic processes. Recent data indicate that in some unicellular eukaryotes that undergo profound differentiation during their life cycle (e. g. kinetoplastid parasites and amoebes), autophagy is essential for the developmental change that allows the cell to adapt to a new host or form spores. This review summarizes the knowledge on the molecular mechanisms of autophagy as well as the cytoplasm-to-vacuole-targeting pathway, pexophagy, mitophagy, ER-phagy, ribophagy and piecemeal microautophagy of the nucleus, all highly selective forms of autophagy that have first been uncovered in yeast species. Additionally, a detailed analysis will be presented on the state of knowledge on autophagy in non-yeast unicellular eukaryotes with emphasis on the role of this process in differentiation.",
keywords = "amoebes, Atg proteins, kinetoplastid parasites, macroautophagy, selective autophagy, yeast, VACUOLE TARGETING PATHWAY, PROTOZOAN PARASITE ENTAMOEBA, SACCHAROMYCES-CEREVISIAE, ENDOPLASMIC-RETICULUM, SELECTIVE AUTOPHAGY, TRYPANOSOMA-CRUZI, DICTYOSTELIUM-DISCOIDEUM, PIECEMEAL MICROAUTOPHAGY, MOLECULAR MACHINERY, LEISHMANIA-MAJOR",
author = "J.A.K.W. Kiel",
year = "2010",
month = "3",
day = "12",
doi = "10.1098/rstb.2009.0237",
language = "English",
volume = "365",
pages = "819 -- 830",
journal = "Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences",
issn = "0962-8436",
publisher = "ROYAL SOC",
number = "1541",

}

RIS

TY - JOUR

T1 - Autophagy in unicellular eukaryotes

AU - Kiel, J.A.K.W.

PY - 2010/3/12

Y1 - 2010/3/12

N2 - Cells need a constant supply of precursors to enable the production of macromolecules to sustain growth and survival. Unlike metazoans, unicellular eukaryotes depend exclusively on the extracellular medium for this supply. When environmental nutrients become depleted, existing cytoplasmic components will be catabolized by (macro) autophagy in order to re-use building blocks and to support ATP production. In many cases, autophagy takes care of cellular housekeeping to sustain cellular viability. Autophagy encompasses a multitude of related and often highly specific processes that are implicated in both biogenetic and catabolic processes. Recent data indicate that in some unicellular eukaryotes that undergo profound differentiation during their life cycle (e. g. kinetoplastid parasites and amoebes), autophagy is essential for the developmental change that allows the cell to adapt to a new host or form spores. This review summarizes the knowledge on the molecular mechanisms of autophagy as well as the cytoplasm-to-vacuole-targeting pathway, pexophagy, mitophagy, ER-phagy, ribophagy and piecemeal microautophagy of the nucleus, all highly selective forms of autophagy that have first been uncovered in yeast species. Additionally, a detailed analysis will be presented on the state of knowledge on autophagy in non-yeast unicellular eukaryotes with emphasis on the role of this process in differentiation.

AB - Cells need a constant supply of precursors to enable the production of macromolecules to sustain growth and survival. Unlike metazoans, unicellular eukaryotes depend exclusively on the extracellular medium for this supply. When environmental nutrients become depleted, existing cytoplasmic components will be catabolized by (macro) autophagy in order to re-use building blocks and to support ATP production. In many cases, autophagy takes care of cellular housekeeping to sustain cellular viability. Autophagy encompasses a multitude of related and often highly specific processes that are implicated in both biogenetic and catabolic processes. Recent data indicate that in some unicellular eukaryotes that undergo profound differentiation during their life cycle (e. g. kinetoplastid parasites and amoebes), autophagy is essential for the developmental change that allows the cell to adapt to a new host or form spores. This review summarizes the knowledge on the molecular mechanisms of autophagy as well as the cytoplasm-to-vacuole-targeting pathway, pexophagy, mitophagy, ER-phagy, ribophagy and piecemeal microautophagy of the nucleus, all highly selective forms of autophagy that have first been uncovered in yeast species. Additionally, a detailed analysis will be presented on the state of knowledge on autophagy in non-yeast unicellular eukaryotes with emphasis on the role of this process in differentiation.

KW - amoebes

KW - Atg proteins

KW - kinetoplastid parasites

KW - macroautophagy

KW - selective autophagy

KW - yeast

KW - VACUOLE TARGETING PATHWAY

KW - PROTOZOAN PARASITE ENTAMOEBA

KW - SACCHAROMYCES-CEREVISIAE

KW - ENDOPLASMIC-RETICULUM

KW - SELECTIVE AUTOPHAGY

KW - TRYPANOSOMA-CRUZI

KW - DICTYOSTELIUM-DISCOIDEUM

KW - PIECEMEAL MICROAUTOPHAGY

KW - MOLECULAR MACHINERY

KW - LEISHMANIA-MAJOR

U2 - 10.1098/rstb.2009.0237

DO - 10.1098/rstb.2009.0237

M3 - Review article

VL - 365

SP - 819

EP - 830

JO - Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

JF - Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

SN - 0962-8436

IS - 1541

ER -

ID: 1898124