Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications

Folkerts, H., 2019, [Groningen]: Rijksuniversiteit Groningen. 220 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Title and contents

    Final publisher's version, 113 KB, PDF document

  • Chapter 1

    Final publisher's version, 818 KB, PDF document

  • Chapter 2

    Final publisher's version, 7 MB, PDF document

  • Chapter 3

    Final publisher's version, 7 MB, PDF document

  • Chapter 4

    Final publisher's version, 3 MB, PDF document

  • Chapter 5

    Final publisher's version, 7 MB, PDF document

  • Chapter 6

    Final publisher's version, 5 MB, PDF document

  • Chapter 7

    Final publisher's version, 2 MB, PDF document

  • Complete thesis

    Final publisher's version, 27 MB, PDF document

  • Propositions

    Final publisher's version, 549 KB, PDF document

  • Hendrik Folkerts
All together the studies in this thesis show that autophagy is an essential survival mechanism for both normal hematopoietic and AML cells and MDS erythroblasts. Altered expression of autophagy-associated genes might have consequences for drug resistance. Therefore, these findings suggest that inhibition of autophagy might be a promising therapeutic strategy for the treatment of AML.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Vellenga, Edo, Supervisor
  • Schuringa, Jan Jacob, Supervisor
  • Coffer, Paul J., Supervisor, External person
  • Touw, I.P., Assessment committee, External person
  • Kampinga, Harrie, Assessment committee
  • den Berg, J.H.M.van, Assessment committee, External person
Award date25-Mar-2019
Place of Publication[Groningen]
Print ISBNs978-94-6375-301-2
Publication statusPublished - 2019

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