Autophagy: Principles and significance in health and diseaseTodde, V., Veenhuis, M. & van der Klei, I. J., Jan-2009, In : Biochimica et biophysica acta-Molecular basis of disease. 1792, 1, p. 3-13 11 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Degradation processes are important for optimal functioning of eukaryotic cells. The two major protein degradation pathways in eukaryotes are the ubiquitin-proteasome pathway and autophagy. This contribution focuses on autophagy. This process is important for survival of cells during nitrogen starvation conditions but also has a house keeping function in removing exhausted, redundant or unwanted cellular components. We present an overview of the molecular mechanism involved in three major autophagy pathways: chaperone mediated autophagy, microautophagy and macroautophagy. Various recent reports indicate that autophagy plays a crucial role in human health and disease. Examples are presented of lysosomal storage diseases and the role of autophagy in cancer, neurodegenerative diseases, defense against pathogens and cell death. (C) 2008 Elsevier B.V. All rights reserved.
|Number of pages||11|
|Journal||Biochimica et biophysica acta-Molecular basis of disease|
|Publication status||Published - Jan-2009|
- Yeast, Autophagy, ATG genes, Vacuole, Lysosome, Autophagosome, VACUOLE TARGETING PATHWAY, YEAST HANSENULA-POLYMORPHA, SELECTIVE PEROXISOME DEGRADATION, PICHIA-PASTORIS REQUIRES, GENOME-WIDE ASSOCIATION, SACCHAROMYCES-CEREVISIAE, CELL-DEATH, PROTEIN-KINASE, PIECEMEAL MICROAUTOPHAGY, CORONAVIRUS REPLICATION