Publication

Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study

Asefa, N. G., Neustaeter, A., Jansonius, N. M. & Snieder, H., 1-Sep-2020, In : Investigative ophthalmology & visual science. 61, 11, p. 25 10 p., 25.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Asefa, N. G., Neustaeter, A., Jansonius, N. M., & Snieder, H. (2020). Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study. Investigative ophthalmology & visual science, 61(11), 25. [25]. https://doi.org/10.1167/iovs.61.11.25

Author

Asefa, Nigus G ; Neustaeter, Anna ; Jansonius, Nomdo M ; Snieder, Harold. / Autonomic Dysfunction and Blood Pressure in Glaucoma Patients : The Lifelines Cohort Study. In: Investigative ophthalmology & visual science. 2020 ; Vol. 61, No. 11. pp. 25.

Harvard

Asefa, NG, Neustaeter, A, Jansonius, NM & Snieder, H 2020, 'Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study', Investigative ophthalmology & visual science, vol. 61, no. 11, 25, pp. 25. https://doi.org/10.1167/iovs.61.11.25

Standard

Autonomic Dysfunction and Blood Pressure in Glaucoma Patients : The Lifelines Cohort Study. / Asefa, Nigus G; Neustaeter, Anna; Jansonius, Nomdo M; Snieder, Harold.

In: Investigative ophthalmology & visual science, Vol. 61, No. 11, 25, 01.09.2020, p. 25.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Asefa NG, Neustaeter A, Jansonius NM, Snieder H. Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study. Investigative ophthalmology & visual science. 2020 Sep 1;61(11):25. 25. https://doi.org/10.1167/iovs.61.11.25


BibTeX

@article{07296c1b77dd440c947ef3c0e58f783f,
title = "Autonomic Dysfunction and Blood Pressure in Glaucoma Patients: The Lifelines Cohort Study",
abstract = "Purpose: We investigated relationship of glaucoma with measurements related to autonomic dysfunction, including heart rate variability (HRV) and blood pressure (BP). Methods: Glaucoma was defined using a questionnaire-based algorithm for 86,841 LifeLines Cohort Study participants. Baseline HRV (root mean square of successive differences [RMSSD]) was calculated from resting electrocardiograms; systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were oscillometric-based measurements. We used a generalized linear mixed model, adjusted for age, age square, sex, body mass index, and familial relationships to assess the relationship of baseline HRV and BP (continuous and quartiles), hypertension, and antihypertensive medication with glaucoma at follow up (median, 3.8 years). Results: The odds ratio (OR) of glaucoma was 0.95 (95% confidence interval [CI], 0.92-0.99) per unit increase in log-transformed RMSSD (in ms), indicating that autonomous dysfunction (low HRV) is associated with a higher risk of glaucoma. Per 10-mm Hg increase in BP, we found ORs of 1.03 (95% CI, 1.01-1.05; P = 0.015) for SBP, 1.01 (95% CI, 0.97-1.05; P = 0.55) for DBP, 1.03 (95% CI, 1.00-1.06; P = 0.083) for MAP, and 1.04 (95% CI, 1.01-1.07; P = 0.006) for PP. The OR for the lowest versus highest RMSSD quartile was 1.15 (95% CI, 1.05-1.27; P = 0.003). The ORs for the highest versus second quartile were 1.09 (95% CI, 0.99-1.19; P = 0.091) for SBP and 1.13 (95% CI, 1.02-1.24; P = 0.015) for PP. Glaucoma was more common among hypertensives (OR, 1.25; 95% CI, 1.16-1.35; P < 0.001); among those using angiotensin-converting enzyme (ACE) inhibitors (OR, 1.35; 95% CI, 1.18-1.55; P < 0.001); and among those using calcium-channel blockers (OR, 1.19; 95% CI, 1.01-1.40; P = 0.039). Conclusions: Low HRV, high SBP, high PP, and hypertension were associated with glaucoma. Longitudinal studies may elucidate if autonomic dysregulation and high BP also predict glaucoma incidence.",
author = "Asefa, {Nigus G} and Anna Neustaeter and Jansonius, {Nomdo M} and Harold Snieder",
year = "2020",
month = sep,
day = "1",
doi = "10.1167/iovs.61.11.25",
language = "English",
volume = "61",
pages = "25",
journal = "Investigative ophthalmology & visual science",
issn = "0146-0404",
publisher = "ASSOC RESEARCH VISION OPHTHALMOLOGY INC",
number = "11",

}

RIS

TY - JOUR

T1 - Autonomic Dysfunction and Blood Pressure in Glaucoma Patients

T2 - The Lifelines Cohort Study

AU - Asefa, Nigus G

AU - Neustaeter, Anna

AU - Jansonius, Nomdo M

AU - Snieder, Harold

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Purpose: We investigated relationship of glaucoma with measurements related to autonomic dysfunction, including heart rate variability (HRV) and blood pressure (BP). Methods: Glaucoma was defined using a questionnaire-based algorithm for 86,841 LifeLines Cohort Study participants. Baseline HRV (root mean square of successive differences [RMSSD]) was calculated from resting electrocardiograms; systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were oscillometric-based measurements. We used a generalized linear mixed model, adjusted for age, age square, sex, body mass index, and familial relationships to assess the relationship of baseline HRV and BP (continuous and quartiles), hypertension, and antihypertensive medication with glaucoma at follow up (median, 3.8 years). Results: The odds ratio (OR) of glaucoma was 0.95 (95% confidence interval [CI], 0.92-0.99) per unit increase in log-transformed RMSSD (in ms), indicating that autonomous dysfunction (low HRV) is associated with a higher risk of glaucoma. Per 10-mm Hg increase in BP, we found ORs of 1.03 (95% CI, 1.01-1.05; P = 0.015) for SBP, 1.01 (95% CI, 0.97-1.05; P = 0.55) for DBP, 1.03 (95% CI, 1.00-1.06; P = 0.083) for MAP, and 1.04 (95% CI, 1.01-1.07; P = 0.006) for PP. The OR for the lowest versus highest RMSSD quartile was 1.15 (95% CI, 1.05-1.27; P = 0.003). The ORs for the highest versus second quartile were 1.09 (95% CI, 0.99-1.19; P = 0.091) for SBP and 1.13 (95% CI, 1.02-1.24; P = 0.015) for PP. Glaucoma was more common among hypertensives (OR, 1.25; 95% CI, 1.16-1.35; P < 0.001); among those using angiotensin-converting enzyme (ACE) inhibitors (OR, 1.35; 95% CI, 1.18-1.55; P < 0.001); and among those using calcium-channel blockers (OR, 1.19; 95% CI, 1.01-1.40; P = 0.039). Conclusions: Low HRV, high SBP, high PP, and hypertension were associated with glaucoma. Longitudinal studies may elucidate if autonomic dysregulation and high BP also predict glaucoma incidence.

AB - Purpose: We investigated relationship of glaucoma with measurements related to autonomic dysfunction, including heart rate variability (HRV) and blood pressure (BP). Methods: Glaucoma was defined using a questionnaire-based algorithm for 86,841 LifeLines Cohort Study participants. Baseline HRV (root mean square of successive differences [RMSSD]) was calculated from resting electrocardiograms; systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were oscillometric-based measurements. We used a generalized linear mixed model, adjusted for age, age square, sex, body mass index, and familial relationships to assess the relationship of baseline HRV and BP (continuous and quartiles), hypertension, and antihypertensive medication with glaucoma at follow up (median, 3.8 years). Results: The odds ratio (OR) of glaucoma was 0.95 (95% confidence interval [CI], 0.92-0.99) per unit increase in log-transformed RMSSD (in ms), indicating that autonomous dysfunction (low HRV) is associated with a higher risk of glaucoma. Per 10-mm Hg increase in BP, we found ORs of 1.03 (95% CI, 1.01-1.05; P = 0.015) for SBP, 1.01 (95% CI, 0.97-1.05; P = 0.55) for DBP, 1.03 (95% CI, 1.00-1.06; P = 0.083) for MAP, and 1.04 (95% CI, 1.01-1.07; P = 0.006) for PP. The OR for the lowest versus highest RMSSD quartile was 1.15 (95% CI, 1.05-1.27; P = 0.003). The ORs for the highest versus second quartile were 1.09 (95% CI, 0.99-1.19; P = 0.091) for SBP and 1.13 (95% CI, 1.02-1.24; P = 0.015) for PP. Glaucoma was more common among hypertensives (OR, 1.25; 95% CI, 1.16-1.35; P < 0.001); among those using angiotensin-converting enzyme (ACE) inhibitors (OR, 1.35; 95% CI, 1.18-1.55; P < 0.001); and among those using calcium-channel blockers (OR, 1.19; 95% CI, 1.01-1.40; P = 0.039). Conclusions: Low HRV, high SBP, high PP, and hypertension were associated with glaucoma. Longitudinal studies may elucidate if autonomic dysregulation and high BP also predict glaucoma incidence.

U2 - 10.1167/iovs.61.11.25

DO - 10.1167/iovs.61.11.25

M3 - Article

C2 - 32931573

VL - 61

SP - 25

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

SN - 0146-0404

IS - 11

M1 - 25

ER -

ID: 134504698