Publication

Automated 3-D method for the correction of axial artifacts in spectral-domain optical coherence tomography images

Antony, B., Abramoff, M. D., Tang, L., Ramdas, W. D., Vingerling, J. R., Jansonius, N. M., Lee, K., Kwon, Y. H., Sonka, M. & Garvin, M. K., 1-Aug-2011, In : Biomedical optics express. 2, 8, p. 2403-2416 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Bhavna Antony
  • Michael D. Abramoff
  • Li Tang
  • Wishal D. Ramdas
  • Johannes R. Vingerling
  • Nomdo M. Jansonius
  • Kyungmoo Lee
  • Young H. Kwon
  • Milan Sonka
  • Mona K. Garvin

The 3-D spectral-domain optical coherence tomography (SD-OCT) images of the retina often do not reflect the true shape of the retina and are distorted differently along the x and y axes. In this paper, we propose a novel technique that uses thin-plate splines in two stages to estimate and correct the distinct axial artifacts in SD-OCT images. The method was quantitatively validated using nine pairs of OCT scans obtained with orthogonal fast-scanning axes, where a segmented surface was compared after both datasets had been corrected. The mean unsigned difference computed between the locations of this artifact-corrected surface after the single-spline and dual-spline correction was 23.36 +/- 4.04 mu m and 5.94 +/- 1.09 mu m, respectively, and showed a significant difference (p <0.001 from two-tailed paired t-test). The method was also validated using depth maps constructed from stereo fundus photographs of the optic nerve head, which were compared to the flattened top surface from the OCT datasets. Significant differences (p <0.001) were noted between the artifact-corrected datasets and the original datasets, where the mean unsigned differences computed over 30 optic-nerve-head-centered scans (in normalized units) were 0.134 +/- 0.035 and 0.302 +/- 0.134, respectively. (C) 2011 Optical Society of America

Original languageEnglish
Pages (from-to)2403-2416
Number of pages14
JournalBiomedical optics express
Volume2
Issue number8
Publication statusPublished - 1-Aug-2011

    Keywords

  • SEGMENTATION, REGISTRATION, ROTTERDAM

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