Attrition-Enhanced Deracemization in the Synthesis of Clopidogrel - A Practical Application of a New DiscoveryMeijden, M. W. V. D., Leeman, M., Gelens, E., Noorduin, W. L., Meekes, H., Enckevort, W. J. P. V., Kaptein, B., Vlieg, E. & Kellogg, R. M., 2009, In : Organic Process Research & Development. 13, 6, p. 1195-1198 4 p.
Research output: Contribution to journal › Article › Academic
The recently discovered technique of deracemization by means of attrition-induced grinding of a solid conglomerate in contact with a solution wherein racemization occurs has been used with a derivative of 2-chlorophenyl glycine, the key chiral component in the synthesis of Clopidogrel (Plavix). Deracemization of the racemate proceeds to a single enantiomer and in essentially absolute enantiomeric excess. Further conversion of enantiomerically pure material to Clopidogrel was achieved in 88% yield.
|Number of pages||4|
|Journal||Organic Process Research & Development|
|Publication status||Published - 2009|
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