At the Center of Autophagy: Autophagosomes

Reggiori, F. & Mauthe, M. 2016 Encyclopedia of Cell Biology: Reference Module in Biomedical Sciences. Elsevier, p. 243-247 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autophagosomes are double-membrane sequestering vesicles that are the hallmark of the intracellular catabolic process called macroautophagy. They are formed by the orchestrated interplay of the AuTophaGy-related (ATG) proteins. The cargo molecules targeted by autophagosomes ranges from long-lived proteins and superfluous or excess organelles to invading pathogens. Autophagosomes finally fuse with lysosomes delivering the sequestered material in the interior of these organelles where it is degraded by resident hydrolases. Autophagy represents a key survival mechanism because it clears the cytoplasm from unwanted and potentially toxic structures, and the autophagosomes are the central stage of it.
Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationReference Module in Biomedical Sciences
Number of pages5
ISBN (Print)978-0-12-394796-3
StatePublished - 2016

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