Publication

Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division

Paridaen, J. T. M. L., Wilsch-Bräuninger, M. & Huttner, W. B., 10-Oct-2013, In : Cell. 155, 2, p. 333-344 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Paridaen, J. T. M. L., Wilsch-Bräuninger, M., & Huttner, W. B. (2013). Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell, 155(2), 333-344. https://doi.org/10.1016/j.cell.2013.08.060

Author

Paridaen, Judith T M L ; Wilsch-Bräuninger, Michaela ; Huttner, Wieland B. / Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. In: Cell. 2013 ; Vol. 155, No. 2. pp. 333-344.

Harvard

Paridaen, JTML, Wilsch-Bräuninger, M & Huttner, WB 2013, 'Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division' Cell, vol. 155, no. 2, pp. 333-344. https://doi.org/10.1016/j.cell.2013.08.060

Standard

Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. / Paridaen, Judith T M L; Wilsch-Bräuninger, Michaela; Huttner, Wieland B.

In: Cell, Vol. 155, No. 2, 10.10.2013, p. 333-344.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Paridaen JTML, Wilsch-Bräuninger M, Huttner WB. Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division. Cell. 2013 Oct 10;155(2):333-344. https://doi.org/10.1016/j.cell.2013.08.060


BibTeX

@article{30df03916c714ee6ba5a836c47937279,
title = "Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division",
abstract = "Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis. Inheritance of the mother centriole, which nucleates the primary cilium, in relation to asymmetric daughter cell behavior has previously been studied. However, the fate of the ciliary membrane upon cell division is unknown. Here, we followed the ciliary membrane in dividing embryonic neocortical stem cells and cultured cells. Ciliary membrane attached to the mother centriole was endocytosed at mitosis onset, persisted through mitosis at one spindle pole, and was asymmetrically inherited by one daughter cell, which retained stem cell character. This daughter re-established a primary cilium harboring an activated signal transducer earlier than the noninheriting daughter. Centrosomal association of ciliary membrane in dividing neural stem cells decreased at late neurogenesis when these cells differentiate. Our data imply that centrosome-associated ciliary membrane acts as a determinant for the temporal-spatial control of ciliogenesis.",
keywords = "ADP-Ribosylation Factors, Animals, Cell Division, Centrioles, Centrosome, Cilia, HEK293 Cells, Humans, Mice, Mitosis, Neural Stem Cells, Journal Article, Research Support, Non-U.S. Gov't",
author = "Paridaen, {Judith T M L} and Michaela Wilsch-Br{\"a}uninger and Huttner, {Wieland B}",
note = "Copyright {\circledC} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = "10",
day = "10",
doi = "10.1016/j.cell.2013.08.060",
language = "English",
volume = "155",
pages = "333--344",
journal = "Cell",
issn = "0092-8674",
publisher = "CELL PRESS",
number = "2",

}

RIS

TY - JOUR

T1 - Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division

AU - Paridaen, Judith T M L

AU - Wilsch-Bräuninger, Michaela

AU - Huttner, Wieland B

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/10/10

Y1 - 2013/10/10

N2 - Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis. Inheritance of the mother centriole, which nucleates the primary cilium, in relation to asymmetric daughter cell behavior has previously been studied. However, the fate of the ciliary membrane upon cell division is unknown. Here, we followed the ciliary membrane in dividing embryonic neocortical stem cells and cultured cells. Ciliary membrane attached to the mother centriole was endocytosed at mitosis onset, persisted through mitosis at one spindle pole, and was asymmetrically inherited by one daughter cell, which retained stem cell character. This daughter re-established a primary cilium harboring an activated signal transducer earlier than the noninheriting daughter. Centrosomal association of ciliary membrane in dividing neural stem cells decreased at late neurogenesis when these cells differentiate. Our data imply that centrosome-associated ciliary membrane acts as a determinant for the temporal-spatial control of ciliogenesis.

AB - Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis. Inheritance of the mother centriole, which nucleates the primary cilium, in relation to asymmetric daughter cell behavior has previously been studied. However, the fate of the ciliary membrane upon cell division is unknown. Here, we followed the ciliary membrane in dividing embryonic neocortical stem cells and cultured cells. Ciliary membrane attached to the mother centriole was endocytosed at mitosis onset, persisted through mitosis at one spindle pole, and was asymmetrically inherited by one daughter cell, which retained stem cell character. This daughter re-established a primary cilium harboring an activated signal transducer earlier than the noninheriting daughter. Centrosomal association of ciliary membrane in dividing neural stem cells decreased at late neurogenesis when these cells differentiate. Our data imply that centrosome-associated ciliary membrane acts as a determinant for the temporal-spatial control of ciliogenesis.

KW - ADP-Ribosylation Factors

KW - Animals

KW - Cell Division

KW - Centrioles

KW - Centrosome

KW - Cilia

KW - HEK293 Cells

KW - Humans

KW - Mice

KW - Mitosis

KW - Neural Stem Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.cell.2013.08.060

DO - 10.1016/j.cell.2013.08.060

M3 - Article

VL - 155

SP - 333

EP - 344

JO - Cell

JF - Cell

SN - 0092-8674

IS - 2

ER -

ID: 53430550