Publication

Astrocytic β2-Adrenergic Receptors and Multiple Sclerosis

De Keyser, J., 2017, Noradrenergic Signaling and Astroglia. HANLEY & BELFUS-ELSEVIER INC, p. 289-299 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

  • Jacques De Keyser

A downregulation of astrocytic β2-adrenergic receptors might play a role in the pathophysiology of multiple sclerosis. It may facilitate autoimmune procsses, leading to the characteristic focal inflammatory demyelinating lesions, by transforming astrocytes into facultative antigen presenting clls and reducing double negative T clls, which are considered to act as regulatory T clls having the capacity of inducing antigen-specific immune toleranc. Downregulation of astrocytic β2-adrenergic receptors may contribute to progressive axonal degeneration by allowing expression of inducible nitric oxide oxidase leading to increased levels of nitric oxide, reducing glycogenolysis leading to impaired formation of lactate as axonal energy sourc, reducing trophic support, and facilitating astrocytic expression of endothelin-1 causing crebral hypoperfusion.

Original languageEnglish
Title of host publicationNoradrenergic Signaling and Astroglia
PublisherHANLEY & BELFUS-ELSEVIER INC
Chapter15
Pages289-299
Number of pages11
ISBN (Electronic)9780128134269
ISBN (Print)9780128050880
Publication statusPublished - 2017

    Keywords

  • Axonal degeneration, Inflammation, Multiple sclerosis, Pathophysiology, β-adrenergic receptors

ID: 112110976