Publication

Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women

de Wit, A. E., Giltay, E. J., de Boer, M. K., Bosker, F. J., van der Mast, R. C., Comijs, H. C., Oude Voshaar, R. C. & Schoevers, R. A., Mar-2019, In : International Journal of Geriatric Psychiatry. 34, 3, p. 463-471 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Wit, A. E., Giltay, E. J., de Boer, M. K., Bosker, F. J., van der Mast, R. C., Comijs, H. C., ... Schoevers, R. A. (2019). Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. International Journal of Geriatric Psychiatry, 34(3), 463-471. https://doi.org/10.1002/gps.5040

Author

de Wit, A E ; Giltay, E J ; de Boer, M K ; Bosker, F J ; van der Mast, R C ; Comijs, H C ; Oude Voshaar, R C ; Schoevers, R A. / Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. In: International Journal of Geriatric Psychiatry. 2019 ; Vol. 34, No. 3. pp. 463-471.

Harvard

de Wit, AE, Giltay, EJ, de Boer, MK, Bosker, FJ, van der Mast, RC, Comijs, HC, Oude Voshaar, RC & Schoevers, RA 2019, 'Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women', International Journal of Geriatric Psychiatry, vol. 34, no. 3, pp. 463-471. https://doi.org/10.1002/gps.5040

Standard

Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. / de Wit, A E; Giltay, E J; de Boer, M K; Bosker, F J; van der Mast, R C; Comijs, H C; Oude Voshaar, R C; Schoevers, R A.

In: International Journal of Geriatric Psychiatry, Vol. 34, No. 3, 03.2019, p. 463-471.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Wit AE, Giltay EJ, de Boer MK, Bosker FJ, van der Mast RC, Comijs HC et al. Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women. International Journal of Geriatric Psychiatry. 2019 Mar;34(3):463-471. https://doi.org/10.1002/gps.5040


BibTeX

@article{3d85075ab22a432890ab1bba74446ef4,
title = "Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women",
abstract = "OBJECTIVES: Older age and Major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and Metabolic Syndrome (MetS) in men, though associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women.METHODS: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons (NESDO) were included. Total testosterone (TT) and sex-hormone binding globulin (SHBG) levels were measured using a second generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.RESULTS: A higher risk for MetS was found in men with low FT and TT (Odds Ratio [OR]: 0.67, 95{\%} confidence interval [95{\%}CI]: 0.47-0.95 and OR: 0.51, 95{\%}CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95{\%}CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose and plasma lipid MetS components at baseline, but not with changes in these components at two-year follow-up. The associations did not significantly differ between MDD patients and controls.CONCLUSIONS: Independently of having MDD, low testosterone levels in men, and in contrast, high testosterone levels in women were significantly associated with MetS and its components.",
keywords = "HEALTH, HORMONE-BINDING GLOBULIN, CARDIOVASCULAR RISK-FACTORS, ANDROGENS, PREDICT, STRESS",
author = "{de Wit}, {A E} and Giltay, {E J} and {de Boer}, {M K} and Bosker, {F J} and {van der Mast}, {R C} and Comijs, {H C} and {Oude Voshaar}, {R C} and Schoevers, {R A}",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = "3",
doi = "10.1002/gps.5040",
language = "English",
volume = "34",
pages = "463--471",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Associations between testosterone and metabolic syndrome in depressed and non-depressed older men and women

AU - de Wit, A E

AU - Giltay, E J

AU - de Boer, M K

AU - Bosker, F J

AU - van der Mast, R C

AU - Comijs, H C

AU - Oude Voshaar, R C

AU - Schoevers, R A

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/3

Y1 - 2019/3

N2 - OBJECTIVES: Older age and Major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and Metabolic Syndrome (MetS) in men, though associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women.METHODS: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons (NESDO) were included. Total testosterone (TT) and sex-hormone binding globulin (SHBG) levels were measured using a second generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.RESULTS: A higher risk for MetS was found in men with low FT and TT (Odds Ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose and plasma lipid MetS components at baseline, but not with changes in these components at two-year follow-up. The associations did not significantly differ between MDD patients and controls.CONCLUSIONS: Independently of having MDD, low testosterone levels in men, and in contrast, high testosterone levels in women were significantly associated with MetS and its components.

AB - OBJECTIVES: Older age and Major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and Metabolic Syndrome (MetS) in men, though associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women.METHODS: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons (NESDO) were included. Total testosterone (TT) and sex-hormone binding globulin (SHBG) levels were measured using a second generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria.RESULTS: A higher risk for MetS was found in men with low FT and TT (Odds Ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose and plasma lipid MetS components at baseline, but not with changes in these components at two-year follow-up. The associations did not significantly differ between MDD patients and controls.CONCLUSIONS: Independently of having MDD, low testosterone levels in men, and in contrast, high testosterone levels in women were significantly associated with MetS and its components.

KW - HEALTH

KW - HORMONE-BINDING GLOBULIN

KW - CARDIOVASCULAR RISK-FACTORS

KW - ANDROGENS

KW - PREDICT

KW - STRESS

U2 - 10.1002/gps.5040

DO - 10.1002/gps.5040

M3 - Article

C2 - 30474223

VL - 34

SP - 463

EP - 471

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 3

ER -

ID: 71291590