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Associations between genetic variations and global motion perception

Kunchulia, M., Kotaria, N., Pilz, K., Kotorashvili, A. & Herzog, M. H., Oct-2019, In : Experimental Brain Research. 237, 10, p. 2729-2734 6 p.

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  • Associations between genetic variations and global motion perception

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DOI

  • Marina Kunchulia
  • Nato Kotaria
  • Karin Pilz
  • Adam Kotorashvili
  • Michael H Herzog
The cholinergic system is known to strongly modulate perceptual and cognitive processes, and the alpha7 subunit of the cholinergic nicotinic receptor (CHRNA7) is broadly expressed within the visual system. Here, we assessed whether genetic variations of CHRNA7 affect coherent motion perception. Motion perception has been shown to decline with age, and it has previously been suggested that the effects of genetic variations are magnified by age. Therefore, we tested both older (n = 62) and younger adults (n = 63). We found that motion coherence thresholds were significantly higher for older compared to younger adults, which is in accordance with previous studies. Interestingly, there was a strong relationship between variants of the SNP rs2337980 of the CHRNA7 and motion direction discrimination. In particular, participants carrying the TC genotype had considerably lower motion coherence thresholds than CC carriers. The effect of genotype did not interact with age. Our results show that genetic variations are associated with perceptual performance, but are unlikely to explain age-related changes.
Original languageEnglish
Pages (from-to)2729-2734
Number of pages6
JournalExperimental Brain Research
Volume237
Issue number10
Early online date20-Aug-2019
Publication statusPublished - Oct-2019

    Keywords

  • Coherent motion, Genetic variations, Cholinergic system, CHRNA7, Aging, AGING VISUAL-SYSTEM, YOUNG-WOMEN SMOKE, MODULATION, MECHANISMS, DEFICIENT, DIRECTION, NICOTINE, ALPHA-7, AUTISM, ACUITY

ID: 93515824